Engineered hemostatic bionanocomposite of poly(lactic acid) electrospun mat and amino‐modified halloysite for potential application in wound healing

One of the essential characteristics of an ideal wound dressing is rapid hemostasis. This study aims to investigate the preparation and the characterization of electrospun poly(lactic acid) and halloysite nanotubes (PLA/HNTs) bionanocomposites with either different percentage of pristine and amino‐m...

Full description

Saved in:
Bibliographic Details
Published in:Polymers for advanced technologies 2021-10, Vol.32 (10), p.3934-3947
Main Authors: Delyanee, Mahsa, Solouk, Atefeh, Akbari, Somaye, Daliri Joupari, Morteza
Format: Article
Language:English
Subjects:
Biological properties
bionanocomposite
Clotting
Dispersion
Electrospinning
halloysite nanotubes (HNTs)
hemostatic property
Hemostatics
Modulus of elasticity
Nanofibers
poly(lactic acid) (PLA)
Polylactic acid
Surface charge
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One of the essential characteristics of an ideal wound dressing is rapid hemostasis. This study aims to investigate the preparation and the characterization of electrospun poly(lactic acid) and halloysite nanotubes (PLA/HNTs) bionanocomposites with either different percentage of pristine and amino‐modified HNTs (i.e., 5, 10, and 20 wt%). The effects of HNT's presence, amount, and modification are evaluated on the physicochemical and biological properties which are essential for hemostatic wound dressing. The energy dispersive spectroscopy indicates HNTs are well embedded and dispersed on PLA nanofibers to induce functional interfacial interactions. The addition of HNTs to the PLA in a concentration of 10 wt% improves moisture properties and increases the Young modulus of mats from 26.4 ± 1.66 to 31.62 ± 1.91 and 40.7 ± 1.99 MPa for pristine and modified HNTs, respectively. Also, the surface charge as an influential factor on hemostasis is increased from −39.1 ± 0.3 to −48.4 ± 0.5 and −43.6 ± 0.2 mV for PLA/pristine and modified HNTs bionanocomposites, respectively. Accordingly, blood clotting formation accelerated from 9 to 4 min for the bionanocomposite mat. Furthermore, biological evaluations show that bionanocomposites have suitable cell supporting. It seems that PLA/amino‐modified HNTs bionanocomposite have potential application for hemostatic wound healing.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.5399