RETRACTED ARTICLE: Porous Zn(II)-Organic Framework with Tetrazolyl Decorated Pores for Selective C2H2 Adsorption and Treatment Activity on Infantile Meningitis

• Published in: Macromolecular research 2021, Vol.29 (9), p.605-612
• Main Authors: Yu, Yang, Yin, Qi-Gai, Ye, Li-Jing, Yu, Hui
• Format: Article
• Language: English
• Subjects: Characterization and Evaluation of Materials; Chemistry; Complex Fluids and Microfluidics; Nanochemistry; Nanotechnology; Physical Chemistry; Polymer Sciences; Soft and Granular Matter
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/s13233-021-9071-y

Via applying a dual-functional tetrazolyl-carboxylic ligand 5-(1H-tetrazole-5-yl)-1,3-bis(3,5-dicarboxylphenyl)-benzene (H 5 TBDPB), a new Zn(II)-containing metal-organic framework (MOF) with the chemical composition of [Zn 6 (HTBDPB) 3 (H 2 O) 6 ]·9DMF·15H 2 O (1) has been successfully prepared. This article methodically explored the gas sorption characteristics of activated 1 for C 2 H 2 , CO 2 , and CH 4 , and it holds a relative large C 2 H 2 sorption capacity of 164.0 cm 3 (STP) g −1 at 298 K and 1 bar with the C 2 H 2 /CH 4 and C 2 H 2 /CO 2 sorption selectivity of 34.8 and 4.6 at 298 K, respectively, revealing its potential application for the selective C 2 H 2 adsorption. Additionally, we studied its application value on the infantile meningitis as well as the related mechanism was evaluated. The results of the bacteria growth curve automatic analysis indicated the compound could decrease the growth of Streptococcus meningitidis bacteria. Besides, the compound could also inhibit the survival genes expression in Streptococcus meningitidis in a dose-dependent manner. Molecular docking simulation has revealed that the carboxyl groups are the donor for the formed hydrogen bonds, while the tetrazole groups are the acceptor for the formed hydrogen bonds, such features make the Zn complex as an attractive candidate for infantile meningitis treatment.