Helicobacter pylori and rheumatoid arthritis

The aim of the research was to evaluate a possible relationship between Helicobacter pylori (H. pylori) and rheumatoid arthritis. The presence of and sero-prevalence of IgG antibodies to H. pylori were determined in 59 Danish rheumatoid-arthritis patients. The sero-prevalence was compared to the pre...

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Bibliographic Details
Published in:Journal of pre-clinical and clinical research 2007-01, Vol.1 (1), p.68
Main Authors: Graff, Lykke B, Andersen, Leif P, Gernow, Anne, Bremmelgaard, Annie, Bonnevie, Olaf, Bondesen, Stig, Bartels, Else M, Danneskiold-Samsøe, Bente
Format: Article
Language:English
Subjects:
Inflammatory diseases
Rheumatoid arthritis
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Summary:The aim of the research was to evaluate a possible relationship between Helicobacter pylori (H. pylori) and rheumatoid arthritis. The presence of and sero-prevalence of IgG antibodies to H. pylori were determined in 59 Danish rheumatoid-arthritis patients. The sero-prevalence was compared to the prevalence of controls and the background population. H. pylori in infected and uninfected patients were compared with regards to clinical and demographic characteristics, and the extent of their inflammatory disease activity. H. pylori was found in 18 patients (31%). The sero-prevalence of H. pylori was 32%, non-significant to the prevalence of controls (36%), and of the background population (26%). H. pylori /HLO positive and H. pylori /HLO negative patients were similar with regards to clinical and demographic characteristics and inflammatory disease activity. Our results did not show an aetiologic relationship between H. pylori and rheumatoid arthritis, but further studies are needed to discard the hypothesis completely.
ISSN:1898-2395
1898-7516