Pilot study of exposure of the male population to organophosphate and pyrethroid pesticides in a region of high agricultural activity (Córdoba, Argentina)

Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides and biomarkers of effects were studied in a population (n=40) residing in an important agricultural area of the province of Córdoba (Argentina). Detection frequencies (DF) higher than 85% were observed for the metabolites of...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-10, Vol.28 (38), p.53908-53916
Main Authors: Filippi, Iohanna, Bravo, Natalia, Grimalt, Joan O., Butinof, Mariana, Lerda, Daniel, Fernández, Ricardo A., Muñoz, Sonia E., Amé, María V.
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers
Chlorpyrifos
Creatinine
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Insecticides
Metabolites
Nitrophenol
Organophosphates
p-Nitrophenol
Parathion
Pesticides
Phenoxybenzoic acid
Population studies
Pyrethroids
Research Article
Trichloro-2-pyridinol
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides and biomarkers of effects were studied in a population (n=40) residing in an important agricultural area of the province of Córdoba (Argentina). Detection frequencies (DF) higher than 85% were observed for the metabolites of pirimiphos (2-diethylamino-6-methylpyrimidin-4-ol –DEAMPY-, median 7.5 μg/g creatinine, DF: 100%), parathion (p-nitrophenol, 0.99 μg/g creatinine, 100%), and chlorpyrifos (3,5,6-trichloro-2-pyridinol, 0.25 μg/g creatinine, 85%). The DEAMPY concentrations doubled the levels found in other studies and were negatively associated with Er-AChE activity, suggesting the appearance of health effects already in environmental exposure levels below established acceptable daily intakes (ADIs). 3-Phenoxybenzoic acid, the metabolite of several PYR pesticides, was also found in all samples. This metabolite was also significantly negatively correlated with Er-AChE, indicating effects of pyrethroid pesticides on the acetylcholine system even at concentrations below the ADI.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-021-14397-1