miR-216b Downregulates Intestinal IL2RB to Inhibit the Invasion of Echinococcus granulosus Eggs in the Kazakh Sheep

ABSTRACT To study the early molecular immunity of Echinococcus granulosus infection in livestock, especially in sheep, the immunohistochemistry, in-situ hybridization was used to study the relationship and the distribution between miR-216b and IL2RB in the intestine tissue of kazakh sheep with resis...

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Bibliographic Details
Published in:Pakistan journal of zoology 2021-10, Vol.53 (5), p.1641
Main Authors: Wang, Xuhai, Li, Xin, Yuan, Fangyuan, Li, Chaocheng, Jia, Bin, Jiang, Song
Format: Article
Language:English
Subjects:
Animals
Antigens
Cattle
Cysts
Cytokines
Echinococcosis
Echinococcus granulosus
Eggs
Gene expression
Genetic aspects
Haplotypes
Hybridization
Immune response
Immune response (cell-mediated)
Immune system
Immunohistochemistry
Infections
Interleukins
Intestine
Livestock
Lymphocytes
Lymphocytes T
Major histocompatibility complex
MicroRNA
MicroRNAs
Oral infection
Physiological aspects
Sheep
Small intestine
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Summary:ABSTRACT To study the early molecular immunity of Echinococcus granulosus infection in livestock, especially in sheep, the immunohistochemistry, in-situ hybridization was used to study the relationship and the distribution between miR-216b and IL2RB in the intestine tissue of kazakh sheep with resistant and non-resistant MHC haplotypes after oral infection with E. granulosus eggs. The results demonstrated that miR-216b negatively regulated IL2RB in the cystic echinococcosis intestinal tissues, and they were differentially expressed in the intestine tissue between the resistant sheep and non-resistant sheep, more widely distributed in the resistant group. These results illustrated that miR-216b and IL2RB activated stronger immune response in the resistant sheep, compared with the non-resistant sheep, and participating in the T cell immune response.
ISSN:0030-9923
DOI:10.17582/journal.pjz/20200102110122