Expression of the ZFX Gene in Mouse Kidney During Postnatal Development

ABSTRACT The relationship of cell proliferation and apoptosis is important in normal kidney development. The ZFX gene is important for regulation of growth, proliferation and differentiation in tissue cells while the Bcl-2 and BAX genes regulate apoptosis. This experiment adopted the real-time fluor...

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Bibliographic Details
Published in:Pakistan journal of zoology 2021-10, Vol.53 (5), p.1867
Main Authors: Wang, Xiangzu, Xi, Jifeng, Jia, Bin, Zhang, Yongsheng, Li, Chaocheng
Format: Article
Language:English
Subjects:
Animal tissues
Apoptosis
Bcl-2 protein
Cancer
Cell differentiation
Cell growth
Cell proliferation
Fetus
Fluorescence
Gene expression
Genetic aspects
Growth
Kidneys
Mammals
Observations
Polymerase chain reaction
Proteins
Stem cells
Zfx gene
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Summary:ABSTRACT The relationship of cell proliferation and apoptosis is important in normal kidney development. The ZFX gene is important for regulation of growth, proliferation and differentiation in tissue cells while the Bcl-2 and BAX genes regulate apoptosis. This experiment adopted the real-time fluorescence quantitative technique to test ZFX, Bcl-2, and BAX expression in mice kidney tissue on 1 d, 7 d, 14 d, 21 d, 42 d, and 90 d after birth. The results showed that with the maturation of mouse kidney, the cell proliferation activity decreased, and the expression of ZFX, Bcl-2, and BAX were down regulated. The ZFX gene may participate in the developmental process of the kidney through the balance of cell proliferation and apoptosis regulation.
ISSN:0030-9923
DOI:10.17582/journal.pjz/20161103071158