The role of ADRB2 gene polymorphisms in malignancies

Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, cl...

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Published in:Molecular biology reports 2021-03, Vol.48 (3), p.2741-2749
Main Authors: Wang, Yaqian, Jiang, Shujuan
Format: Article
Language:English
Subjects:
Adrenergic receptors
Angiogenesis
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Carcinogenesis
Gene polymorphism
Genetic Predisposition to Disease
Histology
Humans
Immunoregulation
Life Sciences
Morphology
Neoplasms - genetics
Polymorphism, Genetic
Prognosis
Receptors, Adrenergic, beta-2 - genetics
Review
Risk Factors
Signal Transduction
Single-nucleotide polymorphism
Transcription
Treatment resistance
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description Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
doi_str_mv 10.1007/s11033-021-06250-y
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subjects Adrenergic receptors
Angiogenesis
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Carcinogenesis
Gene polymorphism
Genetic Predisposition to Disease
Histology
Humans
Immunoregulation
Life Sciences
Morphology
Neoplasms - genetics
Polymorphism, Genetic
Prognosis
Receptors, Adrenergic, beta-2 - genetics
Review
Risk Factors
Signal Transduction
Single-nucleotide polymorphism
Transcription
Treatment resistance
title The role of ADRB2 gene polymorphisms in malignancies
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