New Coumarin and Bioactive Constituents of Chionanthus retusus

A new coumarin derivative, 7-O-methylparamicoumarin A (1), has been isolated from the roots of Chionanthus retusus , together with seven known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (3), quercetin (4), and apigeni...

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Bibliographic Details
Published in:Chemistry of natural compounds 2021-09, Vol.57 (5), p.835-839
Main Authors: Wang, I-Chou, Chen, Li-Chai, Chang, Tsung-Hsien, Chen, Chun-Lin, Sung, Ping-Jyun, Lin, Rong-An, Cheng, Ming-Jen, Hsiao, Jen-Wen, Chen, Jih-Jung
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Coumarin
Oleuropein
Organic Chemistry
Plant Sciences
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Summary:A new coumarin derivative, 7-O-methylparamicoumarin A (1), has been isolated from the roots of Chionanthus retusus , together with seven known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (3), quercetin (4), and apigenin (5) exhibited cytotoxicities with IC 50 values of 13.69 ± 1.10, 10.41 ± 0.79, and 12.25 ± 0.91 μM, respectively, against DLD-1 cell line. Luteolin (3), quercetin (4), and apigenin (5) also exhibited cytotoxicities with IC 50 values of 15.35 ± 1.24, 13.52 ± 0.87, and 19.48 ± 1.26 μM, respectively, against CCRF-CEM cell line. In addition, kaempferol (2), apigenin (5), 3,3′,5,5′,7-pentahydroxyflavanone (6), and oleuropein (8) showed potent inhibition with IC 50 values of 24.84 ± 1.95, 27.18 ± 1.82, 25.18 ± 2.07, and 28.14 ± 1.66 μM, respectively, against LPS-induced NO generation.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-021-03492-x