Photodynamic and Photothermal Effects of Carbon Dot-Coated Magnetite- and Porphyrin-Conjugated Confeito-Like Gold Nanoparticles

Gold nanoparticles (AuNPs) possess the characteristics of both inertness and biocompatibility which enable great biomedical application in biosensors and drug delivery. Confeito-like AuNPs conjugated with porphyrin (TCPP) were synthesized and characterized to clarify the photodynamic and phototherma...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2021-08, Vol.94 (8), p.2079-2088
Main Authors: Do, Thu Thi Anh, Imae, Toyoko
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Biosensors
Carbon
Carbon dots
Conjugation
Gold
Iron oxides
Magnetic properties
Magnetite
Nanoparticles
Porphyrins
Singlet oxygen
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Summary:Gold nanoparticles (AuNPs) possess the characteristics of both inertness and biocompatibility which enable great biomedical application in biosensors and drug delivery. Confeito-like AuNPs conjugated with porphyrin (TCPP) were synthesized and characterized to clarify the photodynamic and photothermal properties. The conjugation of TCPP was performed by covalent binding using L-cysteine or carbon dot-protected iron oxide (Fe3O4@Cdots) as adapted linkages. The product had a great aptitude for photosensitization performance and improved the efficiency of singlet oxygen generation, indicating the possible photodynamic properties in an order of AuNPs < Cdots < TCPP. TCPP could be best used for photodynamic application, and carbon dots and confeito-like AuNPs conjugated with TCPP could improve the effectiveness of photodynamic properties. Moreover, magnetite displayed excellent photothermal property better than that of AuNPs, while Cdots and TCPP do not contribute to the photothermal performance. Thus, this study confirmed that Fe3O4@Cdot-conjugated confeito-like AuNPs are available for both photodynamic and photothermal therapeutic application.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20210192