Improvement Effect of Sweet Basil (Ocimum basilicum L.) Powder Intake on Obese Mice Fed a High-fat and High-sucrose Diet

This study aimed to determine if there are anti-inflammatory and anti-obesity effects of sweet basil, an herb, in mice. Sweet basil was administered as a powder to male C57BL/6JJcl mice, which were divided into three groups: the (control [C], high-fat and high-sucrose diet [H], and high-fat and high...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Oleo Science 2021, Vol.70(9), pp.1317-1323
Main Authors: Kiyose, Chikako, Takeuchi, Haruka, Yabe, Yoshimni, Koike, Tomoya, Sakiya, Kazutaka, Nagase, Mana, Tanaka-Yachi, Rieko, Takahashi-Muto, Chie
Format: Article
Language:English
Subjects:
a high-fat and high-sucrose diet
Adipose tissue
anti-inflammation
anti-obesity
Body weight
Diet
Enlargement
Fatty acids
Food intake
Gene expression
in vivo
Lipid metabolism
Lipids
Liver
Proteins
Sucrose
sweet basil
Weight reduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to determine if there are anti-inflammatory and anti-obesity effects of sweet basil, an herb, in mice. Sweet basil was administered as a powder to male C57BL/6JJcl mice, which were divided into three groups: the (control [C], high-fat and high-sucrose diet [H], and high-fat and high-sucrose diet plus sweet basil powder [HB]) groups. The mice were fed for 12 weeks and the dry sweet basil powder comprised 1% per kg of the diet. From experiment third week, the average body weight was significantly higher in the H group than in the C group. The average body weight was significantly lower in the HB group than in the H group, but food intake did not significantly differ between the H and HB groups. Liver weight was drastically lower in the HB group than in the H group. Perirenal fat weight and epididymal fat weight were not significantly different between the H and HB groups. Therefore, we assumed that body-weight reduction caused by sweet basil powder intake depended on inhibition of liver enlargement. We then examined lipid metabolism-related gene expression in the mice livers. Expression of the sterol response element binding protein 1-c gene tended to be lower in the HB group than in the H group (p=0.056). We speculated that sweet basil inhibited liver enlargement by suppressing fatty acid synthesis. Moreover, expression of the monocyte chemoattractant protein-1 gene in epididymal fat was significantly lower in the HB group than in the H group. Sweet basil powder appears to have a potent anti-inflammatory effect in the adipose tissue of mice fed a high-fat and high-sucrose diet.
ISSN:1345-8957
1347-3352
DOI:10.5650/jos.ess21139