Diversity of SARS-CoV-2 genome among various strains identified in Lucknow, Uttar Pradesh

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a significant challenge worldwide. Rapid genome sequencing of SARS-CoV-2 is going on across the globe to detect mutations and genomic modifications in SARS-CoV-2. In this study, we have sequenced twenty-three SARS-CoV-2 posi...

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Bibliographic Details
Published in:bioRxiv 2021-10
Main Authors: Sahoo, Biswajit, Maurya, Pramod Kumar, Tripathi, Ratnesh Kumar, Agarwal, Jyotsana, Tiwari, Swasti
Format: Article
Language:English
Subjects:
Coronaviruses
COVID-19
Genomes
Genomics
Mutation
N gene
Pandemics
Pathogenicity
Phylogeny
S gene
Severe acute respiratory syndrome coronavirus 2
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a significant challenge worldwide. Rapid genome sequencing of SARS-CoV-2 is going on across the globe to detect mutations and genomic modifications in SARS-CoV-2. In this study, we have sequenced twenty-three SARS-CoV-2 positive samples collected during the first pandemic from the state of Uttar Pradesh, India. We observed a range of already reported mutations (2-22), including; D614G, L452R, Q613H, Q677H, T1027I in the S gene; S194L in the N gene; Q57H, L106F, T175I in the ORF3. Few unreported mutations such as P309S in the ORF1ab gene; T379I in the N gene; and L52F, V77I in the ORF3a gene were also detected. Phylogenetic genome analysis showed similarity with other SARS-CoV-2 viruses reported from Uttar Pradesh. The observed mutations may be associated with SARS-CoV-2 virus pathogenicity or disease severity. Competing Interest Statement The authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2021.10.05.463185