Antituberculous effect of silver nanoparticles

The in vitro experiment, involving 1164 strains of the tuberculosis mycobacteria, exhibited a potentiating effect of silver nanoparticles on known antituberculous preparations in respect of overcoming drug-resistance of the causative agent. The in vitro experiment, based on the model of resistant tu...

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Bibliographic Details
Published in:Journal of physics. Conference series 2011-04, Vol.291 (1), p.012030-7
Main Authors: Kreytsberg, G N, Gracheva, I E, Kibrik, B S, Golikov, I V
Format: Article
Language:English
Subjects:
Assessments
Effectiveness
In vitro testing
Nanocomposites
Nanoparticles
Nanostructure
Physics
Silver
Strain
Tuberculosis
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Summary:The in vitro experiment, involving 1164 strains of the tuberculosis mycobacteria, exhibited a potentiating effect of silver nanoparticles on known antituberculous preparations in respect of overcoming drug-resistance of the causative agent. The in vitro experiment, based on the model of resistant tuberculosis, was performed on 65 white mice. An evident antituberculous effect of the nanocomposite on the basis of silver nanoparticles and isoniazid was proved. Toxicological assessment of the of nanopreparations was carried out. The performed research scientifically establishes efficacy and safety of the nanocomposite application in combination therapy of patients suffering from drug-resistant tuberculosis.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/291/1/012030