Biotribological properties of nano zirconium dioxide and hydroxyapatite-reinforced polyetheretherketone (HA/ZrO2/PEEK) biocomposites

Polyetheretherketone (PEEK) has been considered as an excellent orthopedic implant material due to its similar elastic modulus to that of human bones. However, many obstacles including the bio-inertness nature and inferior osteoconduction of PEEK limit its wide applications in clinics. Nano hydroxya...

Full description

Saved in:
Bibliographic Details
Published in:Iranian polymer journal 2021-11, Vol.30 (11), p.1127-1136
Main Authors: Lv, Mei, Lv, Wenjing, Chen, Haozheng, Zheng, Fei, Liu, Jing, Kong, Fandong, Liu, Shuling, Wang, Litao
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biological activity
Biomedical materials
Bones
Calcification
Ceramics
Chemistry
Chemistry and Materials Science
Coefficient of friction
Composite materials
Composites
Glass
Hydroxyapatite
In vitro methods and tests
Mechanical properties
Medical materials
Modulus of elasticity
Nanoparticles
Natural Materials
Original Research
Orthopaedic implants
Orthopedics
Polyether ether ketones
Polymer Sciences
Tribology
Wear rate
Wettability
Zirconium dioxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polyetheretherketone (PEEK) has been considered as an excellent orthopedic implant material due to its similar elastic modulus to that of human bones. However, many obstacles including the bio-inertness nature and inferior osteoconduction of PEEK limit its wide applications in clinics. Nano hydroxyapatite (HA) and zirconium dioxide (ZrO 2 ) were incorporated into PEEK to fabricate HA/ZrO 2 /PEEK biocomposites. The result of wettability of these biocomposites showed that the introduction of the ZrO 2 and HA nanoparticles in PEEK could enhance its hydrophilic property at 1–2% HA and 1–5% ZrO 2 concentrations. The biotribological properties and bioactivity of PEEK and HA/ZrO 2 /PEEK biocomposites were investigated in detail. The friction coefficient of these biocomposites increased with the increase of frequency and their wear width increased obviously with the increase of load. Biological and tribological experiments indicated that bovine serum possessed the best lubrication performance, and the 1%HA–1%ZrO 2 and 2%HA–5%ZrO 2 samples exhibited the lowest friction coefficient and wear rate. Then, the in vitro tests demonstrated that the HA/ZrO 2 /PEEK biocomposites exhibited improved cell activity and alkaline phosphatase activity than pure PEEK, and both 1%HA/1%ZrO 2 /PEEK and 2%HA/5%ZrO 2 /PEEK biocomposite samples could better promote bone calcification. The PEEK biocomposite with 2 wt% HA and 5 wt% ZrO 2 nanoparticles exhibited the best tribological properties and bioactivity, which could be expected to develop a kind of potential medical material for practical clinical applications. Graphic abstract
ISSN:1026-1265
1735-5265
DOI:10.1007/s13726-021-00972-3