Comparison of Methods for Encapsulation of Acetyl Salicylic Acid in Polyelectrolyte Capsules Based on Chitosan

Multilayer microcapsules with the encapsulated model drug (acetylsalicylic acid) are formed by the layer-by-layer adsorption of natural polysaccharides, chitosan and sodium carboxymethyl cellulose, onto microparticles of calcium carbonate. Three encapsulation methods are considered: physical adsorpt...

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Bibliographic Details
Published in:Russian journal of applied chemistry 2021-07, Vol.94 (7), p.934-939
Main Authors: Shilova, S. V., Mirgaleev, G. M., Tretyakova, A. Ya, Barabanov, V. P.
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
Acids
Adsorption
Aqueous solutions
Calcium carbonate
Carboxymethyl cellulose
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chitosan
Encapsulation
Ethanol
Industrial Chemistry/Chemical Engineering
Macromolecular Compounds and Polymeric Materials
Microencapsulation
Microparticles
Multilayers
Permeability
Polyelectrolytes
Polysaccharides
Salicylic acid
Sodium carboxymethyl cellulose
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Summary:Multilayer microcapsules with the encapsulated model drug (acetylsalicylic acid) are formed by the layer-by-layer adsorption of natural polysaccharides, chitosan and sodium carboxymethyl cellulose, onto microparticles of calcium carbonate. Three encapsulation methods are considered: physical adsorption of acetylsalicylic acid in the pores of calcium carbonate microparticles, coprecipitation of an acid with an inorganic template material during its preparation, and incorporation of an acid into hollow capsules by varying the permeability of their shells. To vary the shell permeability, it is proposed to change the polarity of the solvent by introducing 50 vol% ethanol into an aqueous solution. The method has the highest efficiency in encapsulation of acetylsalicylic acid and does not allow the release of acid from the capsules in acidic environments.
ISSN:1070-4272
1608-3296
DOI:10.1134/S1070427221070107