Antidepressant use in pregnancy and severe cardiac malformations: Danish register‐based study

Objective Studies restricted to live births may underestimate severe teratogenic effects. We address the limitation by including data from both prenatal and postnatal diagnoses of cardiac malformations. Design Register‐based study. Setting Denmark. Population 364 012 singleton pregnancies from 2007...

Full description

Saved in:
Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2021-11, Vol.128 (12), p.1949-1957
Main Authors: Kolding, L, Ehrenstein, V, Pedersen, L, Sandager, P, Petersen, OB, Uldbjerg, N, Pedersen, LH
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - epidemiology
Adult
Antidepressants
Antidepressive Agents - adverse effects
Congenital diseases
Denmark - epidemiology
Echocardiography
Female
Fetuses
Heart
Heart Defects, Congenital - chemically induced
Heart Defects, Congenital - epidemiology
Heart surgery
Human exposure
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Complications - drug therapy
Pregnancy Complications - psychology
Prenatal Care - statistics & numerical data
Prenatal development
Prenatal Exposure Delayed Effects - chemically induced
prenatal ultrasound
Registries
selection bias
Serotonin uptake inhibitors
Serotonin Uptake Inhibitors - adverse effects
SSRI
Teratogenicity
Ultrasonic imaging
Venlafaxine
Venlafaxine Hydrochloride - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Studies restricted to live births may underestimate severe teratogenic effects. We address the limitation by including data from both prenatal and postnatal diagnoses of cardiac malformations. Design Register‐based study. Setting Denmark. Population 364 012 singleton pregnancies from 2007 to 2014. Methods We used data from five nationwide registries. Exposure to antidepressants was measured using redeemed prescriptions. Main outcome measures Pregnancies with cardiac malformations that end in miscarriage, termination, stillbirth, postnatal death or cardiac surgery
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.16772