Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single‐cell approaches, capturing, analysi...

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Bibliographic Details
Published in:Advanced functional materials 2021-10, Vol.31 (41), p.n/a
Main Authors: Niazi, Mostafa, Alizadeh, Effat, Zarebkohan, Amir, Seidi, Khaled, Ayoubi‐Joshaghani, Mohammad Hosein, Azizi, Mehdi, Dadashi, Hamed, Mahmudi, Hossein, Javaheri, Tahereh, Jaymand, Mehdi, Hamblin, Michael R., Jahanban‐Esfahlan, Rana, Amoozgar, Zohreh
Format: Article
Language:English
Subjects:
Biomedical materials
Biomimetics
bioresponsive multitasking hydrogels
biosensors
cell biomimetics
circulating tumor cells
Drug delivery systems
Hydrogels
In vivo methods and tests
Materials science
Metabolic disorders
microneedles
Multitasking
nanodoctors
Needles
single‐cell sequencing
Tissue engineering
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Summary:Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single‐cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor‐specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point‐of‐care testing (POCT), microarrays, single‐cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an “all‐in‐one platform” to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to. Bioresponsive multitasking hydrogels can play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases. These hydrogels are classified into point‐of‐care testing, microarrays, single‐cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202104123