Organs dosimetry in targeted radionuclide therapy

The objective of this study is to assess the patients' effective and organ dose during theranostic applications in Kuwait. In total, eighteen adults' patients were conducted nuclear medicine procedures with 177Lu Dotatate for theranostic purpose in Kuwait Cancer control center (KCCC), Kuwa...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2021-11, Vol.188, p.109668, Article 109668
Main Authors: Alnaaimi, Meshari, Sulieman, Abdelmoneim, Alkhorayef, Mohammed, Salah, Hasan, Alduaij, Musa, Algaily, Mosab, Alomair, O., Alashban, Y., Almohammad, H.I., Bradley, David, Kappas, C.
Format: Article
Language:English
Subjects:
Collimators
Dosimeters
Dosimetry
Lu-177
Lutetium isotopes
Nuclear medicine
Organs
Radiation
Radiation dosage
Radiation risk
Radiation therapy
Radioisotopes
Radiology
Scattering
Theranostic
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Summary:The objective of this study is to assess the patients' effective and organ dose during theranostic applications in Kuwait. In total, eighteen adults' patients were conducted nuclear medicine procedures with 177Lu Dotatate for theranostic purpose in Kuwait Cancer control center (KCCC), Kuwait. Medium energy collimator (MEC) (208 keV Scatter 26% better than 113 keV Scatter 60%) was utilized to obtain scans in definite time intervals ranged from one to 2 h (before voiding), 6:00, 24:00, 48:00, 72:00 h. Patients, tissue and organ radiation doses were computed utilizing OLINDA/EXM Software. The average radiation effective dose (in mSv/MBq) for bladder, liver, and both kidneys (left & right), were 0.36, 0.08, 0.61 & 0.60. The range of the effective dose was from 0.55 mSv to 7.7 mSv. The acquired scans using 177Lu were delivered diagnostic findings. The patients’ effective dose is lower compared to the previous studies. Variation is attributed to the departmental protocol and administered activity. The values of the mean organ dose were comparable and lower than previously published studies. Different organs have different level of doses, which may affected by the presence of the metastatic tumors in the entire organ. •Patients' organs dosimetry in targeted radionuclide therapy were carried out in Kuwait Cancer Control Centre.•A total of 18 patients were undergone theranostic procedures with 177Lu Dotatate.•Organ and total patients doses were calculated using Organ Level INternal Dose Assessment (OLINDA) Software.•Optimization of the PET/CT imaging protocol is recommended to assure that patients received a minimal effective dose.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2021.109668