Effects of exercise and/or β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial

The interaction between exercise and nutritional supplementation is unclear among older adults at risk of sarcopenia. We aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, strength, and physical performance and observe potential resi...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2021-10, Vol.114 (4), p.1371-1385
Main Authors: Osuka, Yosuke, Kojima, Narumi, Sasai, Hiroyuki, Wakaba, Kyohsuke, Miyauchi, Daiji, Tanaka, Kiyoji, Kim, Hunkyung
Format: Article
Language:English
Subjects:
Aged
Body Composition
clinical trial
Dietary Supplements
Double-Blind Method
Double-blind studies
Education
Exercise
Factorial design
Female
Gait
Humans
Muscle strength
Muscle Strength - drug effects
Muscle, Skeletal - drug effects
nutritional supplementation
Older people
Physical Functional Performance
Physical training
Placebos
Residual effects
Resistance training
Sarcopenia
Skeletal muscle
Valerates - administration & dosage
Valerates - pharmacology
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Summary:The interaction between exercise and nutritional supplementation is unclear among older adults at risk of sarcopenia. We aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, strength, and physical performance and observe potential residual effects in older women with low muscle mass. This 12-wk, randomized, double-blind, placebo-controlled, 2 × 2 factorial design (exercise-only, HMB-only, both, and none) trial included 156 women aged 65–79 y with skeletal muscle index
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqab176