AIE-based donor-acceptor-donor fluorenone compound as multi-functional luminescence materials

The development of novel luminescent materials with multi-stimuli responsive and multi-functional properties is required. In this work, we designed and synthesized a novel AIE-based fluorenone derivative, MBPF . The donor-acceptor-donor (D-A-D) structure promoted the intermolecular hydrogen bonding...

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Bibliographic Details
Published in:Materials chemistry frontiers 2021-10, Vol.5 (2), p.758-7517
Main Authors: Du, Xianchao, Su, Huifang, Zhao, Li, Xing, Xiaojing, Wang, Bingnan, Qiu, Dongfang, Wang, Jinyi, Yuan, Mao-Sen
Format: Article
Language:English
Subjects:
Biocompatibility
Crystals
Fluorescence
Hydrogen bonding
Hydrostatic pressure
Luminescence
Monoclonal antibodies
Morphology
Phase transitions
Stimuli
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Summary:The development of novel luminescent materials with multi-stimuli responsive and multi-functional properties is required. In this work, we designed and synthesized a novel AIE-based fluorenone derivative, MBPF . The donor-acceptor-donor (D-A-D) structure promoted the intermolecular hydrogen bonding capacity of the exposed oxygen atom in fluorenone. MBPF displayed three different aggregation morphologies: an amorphous floccule Y-MBPF with yellow-green luminescence, a block crystal O-MBPF with orange luminescence, and a needlelike crystal R-MBPF with red emission. They all exhibited reversible stimuli-response phase transitions to temperature and shear, accompanied by fluorescence switching. The orange crystal O-MBPF was also sensitive to isotropic hydrostatic pressure with prominent and contrasting luminescent conversion. Furthermore, we prepared MBPF nanocrystallites and encapsulated them with DSPE-PEG and the monoclonal antibody cetuximab (C225) to obtain MBPF-C225 NPs, which were biocompatible and photostable. They could be used for specific cancer cell imaging through receptor-mediated endocytosis. A novel fluorenone-based luminescent material with multi-stimuli responsive and multi-functional properties is reported.
ISSN:2052-1537
2052-1537
DOI:10.1039/d1qm00856k