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350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience
GoalAvailable data suggest that SARS-Cov-2 infection is usually mild in children. The aim of this study was to describe clinical and biological features and outcome of Covid 19 in Tunisian infants and newborns.MethodWe reviewed files of patients
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| Published in: | Archives of disease in childhood 2021-10, Vol.106 (Suppl 2), p.A146-A147 |
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| container_end_page | A147 |
| container_issue | Suppl 2 |
| container_start_page | A146 |
| container_title | Archives of disease in childhood |
| container_volume | 106 |
| creator | Rabeh, Rania Ben Missaoui, Nada Yahyaoui, Salem Assidi, Msaddek Mazigh, Sonia Boukthir, Samir |
| description | GoalAvailable data suggest that SARS-Cov-2 infection is usually mild in children. The aim of this study was to describe clinical and biological features and outcome of Covid 19 in Tunisian infants and newborns.MethodWe reviewed files of patients |
| doi_str_mv | 10.1136/archdischild-2021-europaediatrics.350 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_bmj_j</sourceid><recordid>TN_cdi_proquest_journals_2580848592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580848592</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1490-d000de656d5523c53e7c5ef9f66e0f4e1e775b246a3dbf6579dcfc290e1ab8ba3</originalsourceid><addsrcrecordid>eNpdkNtKAzEQhoMoWKvvsOB1ag6bbNa7UjxBQbAeLkMOszalZmuyi15644v6JG6poHg1M_wfM8OHEKZkQimXZya5pQ_ZLcPaY0YYxdCndmPAB9Ol4PKEC7KHRrSUasjLch-NCCEc10qpQ3SU84oQypTiI_Q0oF8fn4vp3QLP2kfMihAbcF1o49BtBxO7XJjoiwhvtk0xnxem6PoYcjCxyCE-rwE7iF2CAt43kAJEB8fooDHrDCc_dYweLi_uZ9d4fnt1M5vOsaVlTbAf_vIghfRCMO4Eh8oJaOpGSiBNCRSqSlhWSsO9baSoau8ax2oC1FhlDR-j093eTWpfe8idXrV9isNJzYQiqlSiZgM13VH2ZfULUKK3PvVfn3rrU__zqQdJ_Bv1QHSD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580848592</pqid></control><display><type>article</type><title>350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience</title><source>Social Science Premium Collection</source><source>Education Collection</source><creator>Rabeh, Rania Ben ; Missaoui, Nada ; Yahyaoui, Salem ; Assidi, Msaddek ; Mazigh, Sonia ; Boukthir, Samir</creator><creatorcontrib>Rabeh, Rania Ben ; Missaoui, Nada ; Yahyaoui, Salem ; Assidi, Msaddek ; Mazigh, Sonia ; Boukthir, Samir</creatorcontrib><description>GoalAvailable data suggest that SARS-Cov-2 infection is usually mild in children. The aim of this study was to describe clinical and biological features and outcome of Covid 19 in Tunisian infants and newborns.MethodWe reviewed files of patients <12 months, diagnosed with Covid 19 and hospitalized in pediatric ‘C’ department of Béchir Hamza children’s hospital between 15 March 2020 and 15 April 2021.ResultsWe enrolled thirteen infants and newborns: 11 boys and 2 girls.Median age was 3 months [10 days; 15 months]. Five were aged between 10 and 28 days, seven were aged between 1 and 12 months. Three patients had serious underlying diseases: two cases of interventricular communication and one case of myelomeningocele and meningitis. Six patients had exposure with persons confirmed to Covid 19. Most frequent signs were: fever (11/13), diarrhea and vomiting (3/13), cough (3/13), nasal congestion and grunting (2/13).On admission, physical examination found high fever in seven cases. Two infants had marbled skin and one newborn had jaundice. Two patients had tachypnea. Median heart rate was 135. Three patients had Oxygen saturation <94%.Laboratory testing found median white blood cell count 9496/mm3 [3980-17200], median neutrophil count 4540/mm3 [480-10260], median lymphocyte count 3370/mm3 [990-8020], median monocyt count 1701/mm3 [990-3370] and median C-reactive-protein 4,45mg/l [0-16]. The patient who had jaundice had total bilirubin level at 182 µmol/L and unconjugated bilirubin level at 169 µmol/L. Five patients had lumbar puncture and were all negative.All patients received symptomatic treatment. Two patients received oxygen through nasal canula and one patient was put on non invasive ventilation. As we received the result of RT PCR, all patients were admitted in isolation ward.Median duration of symptoms was 3 days [3-7 days]. Median hospital stay was 3 days [2-7 days]. Death occurred one patient with interventricular communication. He had cardiogenic shock 3 days after his diagnosis with Covid 19.ConclusionPrevalence of Covid 19 is less in children than in adults. In our case serie of 13 infants, five were newborns. Contamination was caused mostly by another family member. Fever, cough and gastrointestinal signs were the most common symptoms. One death occurred in an infant with interventricular communication. None of our patient had multisystem inflammatory syndrome after his infection.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2021-europaediatrics.350</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Abstracts ; Bilirubin ; Cell number ; Children ; Communication ; Contamination ; Cough ; COVID-19 ; Diarrhea ; Fever ; Heart rate ; Infants ; Infections ; Inflammation ; Jaundice ; Laboratory tests ; Leukocytes (neutrophilic) ; Lymphocytes ; Medical Evaluation ; Medical treatment ; Meningitis ; Neonates ; Newborn babies ; Oxygen ; Patients ; Pediatrics ; Physical Examinations ; Severe acute respiratory syndrome coronavirus 2 ; Vomiting ; Young Children</subject><ispartof>Archives of disease in childhood, 2021-10, Vol.106 (Suppl 2), p.A146-A147</ispartof><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2580848592/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2580848592?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21377,21393,27923,27924,33610,33876,43732,43879,73992,74168</link.rule.ids></links><search><creatorcontrib>Rabeh, Rania Ben</creatorcontrib><creatorcontrib>Missaoui, Nada</creatorcontrib><creatorcontrib>Yahyaoui, Salem</creatorcontrib><creatorcontrib>Assidi, Msaddek</creatorcontrib><creatorcontrib>Mazigh, Sonia</creatorcontrib><creatorcontrib>Boukthir, Samir</creatorcontrib><title>350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>GoalAvailable data suggest that SARS-Cov-2 infection is usually mild in children. The aim of this study was to describe clinical and biological features and outcome of Covid 19 in Tunisian infants and newborns.MethodWe reviewed files of patients <12 months, diagnosed with Covid 19 and hospitalized in pediatric ‘C’ department of Béchir Hamza children’s hospital between 15 March 2020 and 15 April 2021.ResultsWe enrolled thirteen infants and newborns: 11 boys and 2 girls.Median age was 3 months [10 days; 15 months]. Five were aged between 10 and 28 days, seven were aged between 1 and 12 months. Three patients had serious underlying diseases: two cases of interventricular communication and one case of myelomeningocele and meningitis. Six patients had exposure with persons confirmed to Covid 19. Most frequent signs were: fever (11/13), diarrhea and vomiting (3/13), cough (3/13), nasal congestion and grunting (2/13).On admission, physical examination found high fever in seven cases. Two infants had marbled skin and one newborn had jaundice. Two patients had tachypnea. Median heart rate was 135. Three patients had Oxygen saturation <94%.Laboratory testing found median white blood cell count 9496/mm3 [3980-17200], median neutrophil count 4540/mm3 [480-10260], median lymphocyte count 3370/mm3 [990-8020], median monocyt count 1701/mm3 [990-3370] and median C-reactive-protein 4,45mg/l [0-16]. The patient who had jaundice had total bilirubin level at 182 µmol/L and unconjugated bilirubin level at 169 µmol/L. Five patients had lumbar puncture and were all negative.All patients received symptomatic treatment. Two patients received oxygen through nasal canula and one patient was put on non invasive ventilation. As we received the result of RT PCR, all patients were admitted in isolation ward.Median duration of symptoms was 3 days [3-7 days]. Median hospital stay was 3 days [2-7 days]. Death occurred one patient with interventricular communication. He had cardiogenic shock 3 days after his diagnosis with Covid 19.ConclusionPrevalence of Covid 19 is less in children than in adults. In our case serie of 13 infants, five were newborns. Contamination was caused mostly by another family member. Fever, cough and gastrointestinal signs were the most common symptoms. One death occurred in an infant with interventricular communication. None of our patient had multisystem inflammatory syndrome after his infection.</description><subject>Abstracts</subject><subject>Bilirubin</subject><subject>Cell number</subject><subject>Children</subject><subject>Communication</subject><subject>Contamination</subject><subject>Cough</subject><subject>COVID-19</subject><subject>Diarrhea</subject><subject>Fever</subject><subject>Heart rate</subject><subject>Infants</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Jaundice</subject><subject>Laboratory tests</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Medical Evaluation</subject><subject>Medical treatment</subject><subject>Meningitis</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Oxygen</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Physical Examinations</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Vomiting</subject><subject>Young Children</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNpdkNtKAzEQhoMoWKvvsOB1ag6bbNa7UjxBQbAeLkMOszalZmuyi15644v6JG6poHg1M_wfM8OHEKZkQimXZya5pQ_ZLcPaY0YYxdCndmPAB9Ol4PKEC7KHRrSUasjLch-NCCEc10qpQ3SU84oQypTiI_Q0oF8fn4vp3QLP2kfMihAbcF1o49BtBxO7XJjoiwhvtk0xnxem6PoYcjCxyCE-rwE7iF2CAt43kAJEB8fooDHrDCc_dYweLi_uZ9d4fnt1M5vOsaVlTbAf_vIghfRCMO4Eh8oJaOpGSiBNCRSqSlhWSsO9baSoau8ax2oC1FhlDR-j093eTWpfe8idXrV9isNJzYQiqlSiZgM13VH2ZfULUKK3PvVfn3rrU__zqQdJ_Bv1QHSD</recordid><startdate>20211011</startdate><enddate>20211011</enddate><creator>Rabeh, Rania Ben</creator><creator>Missaoui, Nada</creator><creator>Yahyaoui, Salem</creator><creator>Assidi, Msaddek</creator><creator>Mazigh, Sonia</creator><creator>Boukthir, Samir</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20211011</creationdate><title>350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience</title><author>Rabeh, Rania Ben ; Missaoui, Nada ; Yahyaoui, Salem ; Assidi, Msaddek ; Mazigh, Sonia ; Boukthir, Samir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1490-d000de656d5523c53e7c5ef9f66e0f4e1e775b246a3dbf6579dcfc290e1ab8ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abstracts</topic><topic>Bilirubin</topic><topic>Cell number</topic><topic>Children</topic><topic>Communication</topic><topic>Contamination</topic><topic>Cough</topic><topic>COVID-19</topic><topic>Diarrhea</topic><topic>Fever</topic><topic>Heart rate</topic><topic>Infants</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Jaundice</topic><topic>Laboratory tests</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Medical Evaluation</topic><topic>Medical treatment</topic><topic>Meningitis</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Oxygen</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Physical Examinations</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Vomiting</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabeh, Rania Ben</creatorcontrib><creatorcontrib>Missaoui, Nada</creatorcontrib><creatorcontrib>Yahyaoui, Salem</creatorcontrib><creatorcontrib>Assidi, Msaddek</creatorcontrib><creatorcontrib>Mazigh, Sonia</creatorcontrib><creatorcontrib>Boukthir, Samir</creatorcontrib><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabeh, Rania Ben</au><au>Missaoui, Nada</au><au>Yahyaoui, Salem</au><au>Assidi, Msaddek</au><au>Mazigh, Sonia</au><au>Boukthir, Samir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience</atitle><jtitle>Archives of disease in childhood</jtitle><stitle>Arch Dis Child</stitle><date>2021-10-11</date><risdate>2021</risdate><volume>106</volume><issue>Suppl 2</issue><spage>A146</spage><epage>A147</epage><pages>A146-A147</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><abstract>GoalAvailable data suggest that SARS-Cov-2 infection is usually mild in children. The aim of this study was to describe clinical and biological features and outcome of Covid 19 in Tunisian infants and newborns.MethodWe reviewed files of patients <12 months, diagnosed with Covid 19 and hospitalized in pediatric ‘C’ department of Béchir Hamza children’s hospital between 15 March 2020 and 15 April 2021.ResultsWe enrolled thirteen infants and newborns: 11 boys and 2 girls.Median age was 3 months [10 days; 15 months]. Five were aged between 10 and 28 days, seven were aged between 1 and 12 months. Three patients had serious underlying diseases: two cases of interventricular communication and one case of myelomeningocele and meningitis. Six patients had exposure with persons confirmed to Covid 19. Most frequent signs were: fever (11/13), diarrhea and vomiting (3/13), cough (3/13), nasal congestion and grunting (2/13).On admission, physical examination found high fever in seven cases. Two infants had marbled skin and one newborn had jaundice. Two patients had tachypnea. Median heart rate was 135. Three patients had Oxygen saturation <94%.Laboratory testing found median white blood cell count 9496/mm3 [3980-17200], median neutrophil count 4540/mm3 [480-10260], median lymphocyte count 3370/mm3 [990-8020], median monocyt count 1701/mm3 [990-3370] and median C-reactive-protein 4,45mg/l [0-16]. The patient who had jaundice had total bilirubin level at 182 µmol/L and unconjugated bilirubin level at 169 µmol/L. Five patients had lumbar puncture and were all negative.All patients received symptomatic treatment. Two patients received oxygen through nasal canula and one patient was put on non invasive ventilation. As we received the result of RT PCR, all patients were admitted in isolation ward.Median duration of symptoms was 3 days [3-7 days]. Median hospital stay was 3 days [2-7 days]. Death occurred one patient with interventricular communication. He had cardiogenic shock 3 days after his diagnosis with Covid 19.ConclusionPrevalence of Covid 19 is less in children than in adults. In our case serie of 13 infants, five were newborns. Contamination was caused mostly by another family member. Fever, cough and gastrointestinal signs were the most common symptoms. One death occurred in an infant with interventricular communication. None of our patient had multisystem inflammatory syndrome after his infection.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><doi>10.1136/archdischild-2021-europaediatrics.350</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Abstracts Bilirubin Cell number Children Communication Contamination Cough COVID-19 Diarrhea Fever Heart rate Infants Infections Inflammation Jaundice Laboratory tests Leukocytes (neutrophilic) Lymphocytes Medical Evaluation Medical treatment Meningitis Neonates Newborn babies Oxygen Patients Pediatrics Physical Examinations Severe acute respiratory syndrome coronavirus 2 Vomiting Young Children |
| title | 350 SARS-CoV-2 infection in infants and newborns: a tunisian single-centre experience |
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