292 Iron deficiency in children with asthma, a predictor of severity and disease control

• Published in: Archives of disease in childhood 2021-10, Vol.106 (Suppl 2), p.A124-A124
• Main Authors: Dudnyk, Veronika, Khromykh, Kateryna, Vasyl, Zhmurchuk
• Format: Article
• Language: English
• Subjects: Abstracts; Asthma; Child Advocacy; Children; Childrens Rights; Disease control; Ferritin; Health risks; Human rights; Iron; Iron deficiency; Nutrient deficiency; Patients; Pediatrics; Risk assessment; Statistical methods; Transferrin receptors; Transferrins
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2021-europaediatrics.292

Aim of the study was to investigate influence of iron deficiency on severity and control of asthma in children.We have examined 227 children aged 6 to 17 years, patients with asthma. The average age of the surveyed patients amounted to (9.87 ± 0.22) years. The diagnosis of asthma was established in accordance with ICD 10 and order of the Ministry of Health of Ukraine on asthma in children no 868 from08.10.2013 with the recommendations of the ‘Global Initiative on Bronchial Asthma’ (GINA, 2018). The work started after receiving the consent of the patient and his parents to participate in the study in compliance with the provisions of the UN Convention on the Rights of the Child. Materials of the study do not deny the international Code of Medical Ethics (1983) and the laws of Ukraine correspond to the basic bioethical norms of the Helsinki Declaration, adopted by the General Assembly of the World Medical Association, the Council of Europe Convention on human Rights and Biomedicine (1977).CBC with morphometric parameters (MCV, MCH, MCHC, RBC, RDW, HCT) was performed with the help of Hematologic Analyzer Gobas Micros 18. Iron complex (serum iron, ferritin, transferrin receptors and sTfR/log ferritin) ELISA kits. Statistical methods (SPSS Statistic 20th edition).In assessing the risk of asthma in various severity depending on the serum iron content, there is definitely a significant increase in chances that the persistence of moderate to moderate and severe degrees in children with iron content in blood less than 10 μmol/L in 1.537 (OR = 1.537; 95% CI 1.061 – 3.106) and 2.375 (OR = 2.375; 95% CI 1.870 – 6.482) times respectively.While children with no iron deficiency grew the chances of persistent mild asthma in 1.916 times (OR = 1.916; 95% CI 1.696 – 5.271).The level of control of progress of the asthma also depended on the iron content of serum. Thus, the risks of uncontrolled asthma have increased 7.852 times in children with existing iron deficiency (less than 10 μmol/l) (OR = 7.852; 95% CI 3.050 – 20.213). Children with iron deficiency reliably decreased the chances of controlled asthma in 1.472 times (OR = 0.528; 95% CI 0.414 – 0.673), and in children with normal serum iron, the chances of a high level control of a course of asthma increased by 4.146 times (OR = 4.146; 95% CI 1.923 – 8.938).In children with an asthma, iron deficiency reliably decreased the chances of controlled disease compared with patients with normal serum iron in 1.472 times.