186 Cardiac involvement and short-term outcomes of SARS COV 2 infected patients with pediatric multi-systemic inflammatory syndrome at an emergency clinical setting in Bucharest

• Published in: Archives of disease in childhood 2021-10, Vol.106 (Suppl 2), p.A79-A79
• Main Authors: Jurca, Ana Maria, Bejan, Ioana, Cotora, Evelina Aloma, Olteanu, Carmen-Cristina
• Format: Article
• Language: English
• Subjects: Abstracts; Aneurysm; Children; Complications; Coronary artery; Coronary vessels; Effusion; EKG; Emergency medical services; Fever; Health care; Heart; Inflammation; Mucocutaneous lymph node syndrome; Multisystem inflammatory syndrome in children; Pandemics; Patients; Pediatrics; Regurgitation; Septic shock; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Toxic shock syndrome; Ventricle
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2021-europaediatrics.186

Pediatric multi-systemic inflammatory syndrome (PIMS) has gained attention throughout the medical world due to the ongoing SARS COV 2 pandemic. Being a systemic inflammatory response, cardiovascular complications are no exception, thus awareness of such conditions must be raised, as well as of prompt and accurate diagnosis and treatment. Attention is particularly brought to PIMS due to the fact that symptoms of it overlap with Kawasaki disease and toxic shock syndrome. The aim of this paper is to present cardiac findings and short-term outcomes in children with PIMS admitted to one of the main pediatric emergency health care units in Romania.This current paper draws data from a single center, and is an observational, prospective study. The number of patients that were included in this study is 26, with age range between 1 month and 17 years, hospitalized between December 2020 and April 2021 in the ‘Grigore Alexandrescu’ Emergency Hospital for Children, Bucharest. The main criterion for inclusion was PIMS as defined by CDC/WHO case definition. Out of all symptoms, persistent fever and gastrointestinal conditions were de most frequent ones (88% and 69%, respectively).Cardiac involvement was found in 11 patients (42%), being represented by: left ventricular dysfunction (26%), coronary artery abnormalities (15%), atrioventricular valve regurgitation (30%), with only one patient showing pericardial effusion and one an ECG anomaly. Improvement of initial clinical symptoms was paralleled by alleviation of cardiac symptomatology, as well as normalization of cardiac and inflammatory laboratory findings.Our study shows that cardiac involvement is frequent in pediatric population with systemic inflammatory syndrome and we believe that PIMS in SARS COV 2 infected patients should be thoroughly screened and treated by a multi-disciplinary team. 24 out of 26 patients were fully recovered and discharged without sequelae, but two patients with persistent coronary artery aneurysmal findings.