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113 Umbilical cord blood cytokines TNFα and IFN γ levels increased in children born to mothers who are obese

IntroductionMaternal obesity is considered one of the several key factors that affect development of the immune system of newborns. Experimental and clinical data indicate an increased risk of developing autoimmune, allergic diseases and obesity in the offspring of obese mothers. The main mechanisms...

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Bibliographic Details
Published in:Archives of disease in childhood 2021-10, Vol.106 (Suppl 2), p.A48-A48
Main Authors: Novikova, VP, Petrenko, Yu V, Ivanov, DO, Prokopyeva, NE, Gurina, OP, Blinov, AE, Varlamova, ON, Kosenkova, TV, Boytsova, EA
Format: Article
Language:English
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Summary:IntroductionMaternal obesity is considered one of the several key factors that affect development of the immune system of newborns. Experimental and clinical data indicate an increased risk of developing autoimmune, allergic diseases and obesity in the offspring of obese mothers. The main mechanisms of the relationship between mother’s body weight and the immune system of a newborn person remain poorly understood.ObjectivesAim of this study was to analyze the cytokine status of umbilical cord blood of children born to mothers with obesity.MethodsUmbilical cord blood samples were taken from 65 children born to thin (n = 24), with overweight (n = 9) and obese mothers (n = 32). The levels of TNFα, TGFβ1, IL 18, IL 13, IL10 and IFN γ were quantified by IFA. Statistical processing of data was performed on a personal computer using licensed computer software ‘Microsoft Excel 2016’ and ‘STATISTICA 12’. The Student t-test value was determined while analyzing the distribution of quantitative data. The criterion of statistical significance level was p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2021-europaediatrics.113