Duplex modification of hydroxyapatite using co-substitution and dual deposition

• Published in: Materials letters 2021-12, Vol.304, p.130554, Article 130554
• Main Authors: Guo, Chao, Niu, Yi
• Format: Article
• Language: English
• Subjects: Antiinfectives and antibacterials; Bioceramics; Biomaterials; Chemical reduction; Co-substitution; Copper; Deposition; Dual deposition; Hydroxyapatite; Materials science; Nanoparticles; Substitutes; Zinc oxide
• ISSN: 0167-577X; 1873-4979
• DOI: 10.1016/j.matlet.2021.130554

Hydroxyapatite nanoparticle (nano-HA) is duplex modified by co-substitution of copper and zinc ions and subsequent dual deposition of zinc oxide and copper nanoparticles to realize an integration of the strong early release and sustainable long-term release of the antibacterial elements. Co-substitution improves the dual deposition effect. [Display omitted] •Nano-HA was duplex modified by co-substitution and dual deposition.•Co-substitution improves the deposition effect of ZnO and Cu simultaneously.•Duplex modification brings a strong antibacterial ability to nano-HA. Hydroxyapatite (HA) is a famous bioceramic. Nevertheless, weak antibacterial ability prevents the further application of HA. In the present work, hydroxyapatite nanoparticle (nano-HA) was duplex modified using co-substitution and dual deposition to improve its antibacterial ability. Nano-HA with a pure HA structure and co-substituted with copper and zinc ions was obtained by a modified precipitation method. Zinc oxide and copper nanoparticles were successfully deposited on the surface of the co-substituted nano-HA using a two-step liquid chemical reduction method. The result of element analysis demonstrates that the co-substitution treatment improves the subsequent dual deposition effect. The result of the antibacterial test indicates that the duplex modification significantly promotes the antibacterial ability of HA.