EDTA-β-cyclodextrin functionalized graphene for electrochemical detection and scavenge of DPPH radical

• Published in: Journal of applied electrochemistry 2021-12, Vol.51 (12), p.1731-1739
• Main Authors: Zuo, Yu, Han, Yujie, Zhang, Guojuan, Fan, Lifang, Liu, Zhiguang, Guo, Yujing
• Format: Article
• Language: English
• Subjects: Antioxidants; Chemical sensors; Chemistry; Chemistry and Materials Science; Coordination compounds; Cyclodextrins; Electrical properties; Electrochemical analysis; Electrochemistry; Ethylenediaminetetraacetic acids; Fourier transforms; Free radicals; Glassy carbon; Graphene; Inclusion complexes; Industrial Chemistry/Chemical Engineering; Infrared spectra; Infrared spectroscopy; Morphology; Nanocomposites; Oxidation; Photoelectrons; Physical Chemistry; Research Article; Scavenging; Sensors; Signal processing; Spectrum analysis; Supramolecular compounds; Surface area; Synthesis; X ray photoelectron spectroscopy
• ISSN: 0021-891X; 1572-8838
• DOI: 10.1007/s10800-021-01598-2

In this work, a novel and robust electrochemical sensor was developed by modifying EDTA and β-cyclodextrin functionalized reduced graphene oxide (EDTA-β-CD-rGO) onto the Glassy carbon electrodes (GCE) to quantify 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH). The morphology and structures of the nanocomposite were characterized by the UV–vis spectroscopy, Fourier transform infrared (FT-IR) spectra, Scanning electronic microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The nanocomposite exhibits great electrochemical signal enhancement towards DPPH oxidation, which attributes to the good electrical properties and high specific surface area of rGO along with the enrichment of amounts of DPPH onto the EDTA-β-CD-rGO/GCE by forming host-guest inclusion complex and chelated compounds with β-CD and EDTA, respectively. Under the optimal conditions, the linear range for DPPH was from 1.0 × 10 − 8 to 0.01 mol/L with a low detection limit of 3.0 × 10 − 9  mol/L. The sensor also showed the advantages of simple preparation, low cost, good stability and repeatability. These characteristics make the sensor promising for the detection of DPPH. Moreover, EDTA-β-CD-rGO showed strong DPPH scavenging activity, and it can be used as an artificially synthesized antioxidant. Graphic abstract EDTA-β-CD-rGO has been successfully synthesized via hydrothermal process. The nanocomposite shows great electrochemical signal enhancement towards DPPH oxidation not only owing to the large surface area and good electrical properties of rGO, but also due to incorporating amount of DPPH on the electrode by forming stable host–guest inclusion complexes and chelate compound with the presence of β-CD and EDTA, respectively. Meanwhile, EDTA-β-CD-rGO showed strong DPPH scavenging activity, and it can be used as an artificially synthesized antioxidant.