Gellan hydrogel-template synthesis of Au/MnO2 with enhanced photothermal conversion performance for localized cancer therapy

Owing to its excellent biocompatibility, abundant functional groups and injectability, the gellan hydrogel is widely used in the biomedical field. In this work, a Au/MnO2@GG nanocomposite hydrogel was prepared by a one-pot method using the gellan hydrogel as a template. The obtained Au/MnO2@GG exhib...

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Bibliographic Details
Published in:New journal of chemistry 2021-10, Vol.45 (40), p.19065-19072
Main Authors: Liu, Yandi, Hao, Yijun, Wu, Yingjiao, Lu, Sha, Li, Juan, Zhou, Zhijun
Format: Article
Language:English
Subjects:
Ablation
Anticancer properties
Biocompatibility
Biomedical materials
Efficiency
Energy conversion efficiency
Energy dissipation
Functional groups
Gold
Hydrogels
In vivo methods and tests
Manganese dioxide
Nanocomposites
Near infrared radiation
Photothermal conversion
Shear thinning (liquids)
Stability
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Summary:Owing to its excellent biocompatibility, abundant functional groups and injectability, the gellan hydrogel is widely used in the biomedical field. In this work, a Au/MnO2@GG nanocomposite hydrogel was prepared by a one-pot method using the gellan hydrogel as a template. The obtained Au/MnO2@GG exhibits a broad plasmon-enhanced absorption in the near-infrared region. As a result, the nanocomposite hydrogel has an enhanced photothermal conversion efficiency of 71.3% at 808 nm, superior to those of MnO2@GG (27.1%) and Au@GG (25.7%) alone. The local surface plasmon resonance induced by Au could transfer energy to MnO2, and thus improve the photothermal conversion efficiency through non-radiative energy dissipation. Moreover, the nanocomposite hydrogel displays excellent biocompatibility, long-term stability, good shear-thinning and self-recovery properties. In vivo antitumor studies proved that the nanocomposite hydrogel could completely ablate the solid tumors under NIR illumination. This work may encourage the development of more advanced nanocomposite materials with high photothermal conversion efficiency, stability, and multiple functionalities.
ISSN:1144-0546
1369-9261
DOI:10.1039/d1nj03714e