The Rat Heart in the Prenatal and Postnatal Periods of Ontogenesis

Rats are the most common laboratory animals that are used in experiments to evaluate the cardiotoxic and, particularly, teratogenic effects of therapeutic agents. For correct interpretation of results of experimental studies, it is necessary to have a detailed understanding of the specific features...

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Bibliographic Details
Published in:Russian journal of developmental biology 2021-09, Vol.52 (5), p.287-300
Main Authors: Ivanova, V. V., Milto, I. V., Serebrjakova, O. N., Sukhodolo, I. V.
Format: Article
Language:English
Subjects:
Animal Anatomy
Biomedical and Life Sciences
Cardiomyocytes
Developmental Biology
Diploids
Histology
Laboratory animals
Life Sciences
Morphogenesis
Morphology
Myocardium
Reviews
Teratogenicity
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Summary:Rats are the most common laboratory animals that are used in experiments to evaluate the cardiotoxic and, particularly, teratogenic effects of therapeutic agents. For correct interpretation of results of experimental studies, it is necessary to have a detailed understanding of the specific features of the development and structure of the heart of laboratory animals. The cardiac morphogenesis in rats, compared with that of humans, has the following specific features: (1) the peak of proliferative activity of cardiomyocytes occurs in the late stages of the prenatal period of ontogenesis, (2) the transition of the myocardium from hyperplastic to hypertrophic growth occurs in the early postnatal period of ontogenesis, and (3) the hypertrophic type of myocardial growth consists in the formation of cardiomyocytes with several diploid nuclei (multinucleated cardiomyocytes).
ISSN:1062-3604
1608-3326
DOI:10.1134/S1062360421050039