Microfluidic focusing of microparticles utilizing negative magnetophoresis and oscillatory flow

Focusing of biological particles has important applications in the fields of biology, medicine, chemistry and environment. The emergence of microfluidic technology has brought new opportunities for the manipulation of biological particles. However, existing methods generally produce a relatively lar...

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Bibliographic Details
Published in:Microfluidics and nanofluidics 2021-12, Vol.25 (12), Article 97
Main Authors: Xue, Chun-Dong, Zhao, Jia-Ming, Sun, Zhong-Ping, Na, Jing-Tong, Li, Yong-Jiang, Qin, Kai-Rong
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biological effects
Biology
Biomedical Engineering and Bioengineering
Engineering
Engineering Fluid Dynamics
Magnetic field
Magnetic fields
Medical sciences
Microfluidics
Microparticles
Nanotechnology and Microengineering
Oscillating flow
Oscillatory flow
Production methods
Research Paper
Shear stress
Temperature effects
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Summary:Focusing of biological particles has important applications in the fields of biology, medicine, chemistry and environment. The emergence of microfluidic technology has brought new opportunities for the manipulation of biological particles. However, existing methods generally produce a relatively large shear stress or thermal effect on biological particles, which may cause negative biological effects during manipulation, especially for sensitive bioparticles. Herein, we propose a novel strategy for microfluidic focusing of microparticles based on negative magnetophoresis and oscillatory flow. A simple and efficient simulation model is first developed to calculate the motion of particles under magnetic field and fluid field. The non-monotonic size dependence of particle focusing is then revealed and elaborately analyzed. Furthermore, the effects of oscillatory flow field and magnetic field on particle focusing are quantitatively investigated and the particle size range for effective focusing in our proposed chip is provided. The proposed strategy of microfluidic focusing can guide the real applications such as enrichment and separation of sensitive biological particles.
ISSN:1613-4982
1613-4990
DOI:10.1007/s10404-021-02497-w