ANTITUMOR PROPERTIES OF VEGETABLE OIL EXTRACT FROM GREEN MICROALGA COELASTRELLA SP

Microalgae are of great importance for the production of original natural substances of interest for food, health or biotechnological applications. Mass cultures of green microalgae are used for production of carotenoids such β-carotene, astaxanthin, canthaxanthin, lutein etc. The aim of this study...

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Bibliographic Details
Published in:Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2021-10, Vol.11 (2), p.e2744
Main Authors: Toshkova-Yotova, Tanya, Georgieva, Ani, Todorova, Katerina, Pilarski, Plamen, Toshkova, Reneta
Format: Article
Language:English
Subjects:
Algae
Anticancer properties
Apoptosis
Aquatic microorganisms
Astaxanthin
Carotene
Carotenoids
Cell proliferation
Fluorescence
Fluorescence microscopy
Food industry
Lutein
Organic solvents
Solvents
Sunflower oil
Sunflowers
Tumor cells
Vegetable oils
Vegetables
β-Carotene
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Summary:Microalgae are of great importance for the production of original natural substances of interest for food, health or biotechnological applications. Mass cultures of green microalgae are used for production of carotenoids such β-carotene, astaxanthin, canthaxanthin, lutein etc. The aim of this study was to obtain an oil extract from a Bulgarian green microalga strain Coelastrella sp. BGV and to assess its anticancer and apoptogenic activity in vitro against human tumor cells HeLa by means of MTT and fluorescence microscopy analyses. The results showed that the oil extract obtained by a direct extraction using a common vegetable oil reduces proliferation and induces apoptosis in HeLa cells. In contrast to widely used organic solvents for the production of carotenoids, the applied bio-solvent (sunflower oil) can be a valuable alternative approach for the needs of the food industry. The resulting oil extract showed promising antitumor and apoptosis-inducing activity against HeLa cells in vitro and potential for future use in practice.
ISSN:1338-5178
1338-5178
DOI:10.15414/jmbfs.2744