Effect of 1,1-Dimethylhydrazine on the Induction of Peptides in Galleria Mellonella Hemolymph

Liquid chromatography and MALDI mass spectrometry have been employed to study the effect of 1,1-dimethylhydrazine and its acetone hydrazone on peptide composition of hemolymph of Galleria mellonella caterpillar larvae. It has been found that the following components arise in the hemolymph: induced l...

Full description

Saved in:
Bibliographic Details
Published in:Colloid journal of the Russian Academy of Sciences 2021-09, Vol.83 (5), p.642-650
Main Authors: Polunin, K. E., Fedotkina, O. S., Polunina, I. A., Buryak, A. K.
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Coliforms
Dimethylhydrazines
E coli
Hydrazones
Ions
Larvae
Liquid chromatography
Mass spectrometry
Peptides
Polymer Sciences
Surfaces and Interfaces
Thin Films
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liquid chromatography and MALDI mass spectrometry have been employed to study the effect of 1,1-dimethylhydrazine and its acetone hydrazone on peptide composition of hemolymph of Galleria mellonella caterpillar larvae. It has been found that the following components arise in the hemolymph: induced low-molecular-mass peptide products with masses of 1–3 kDa, fragments and methylated modifications of previously-known antibacterial peptides of Galleria mellonella, as well as six unknown peptides that exhibit bactericidal activity with respect to Gram-negative bacteria Escherichia coli .
ISSN:1061-933X
1608-3067
DOI:10.1134/S1061933X21050124