Sulfated Alginate Hydrogels Prolong the Therapeutic Potential of MSC Spheroids by Sequestering the Secretome (Adv. Healthcare Mater. 21/2021)

Mesenchymal Stromal Cells In article number 2101048 by J. Kent Leach and co‐workers, spheroids of mesenchymal stromal cells (MSCs) secrete high levels of relevant growth factors (GFs) for tissue regeneration. Sulfated alginate can sequester these GFs through ionic interactions, allowing increased th...

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Bibliographic Details
Published in:Advanced healthcare materials 2021-11, Vol.10 (21), p.n/a
Main Authors: Gionet‐Gonzales, Marissa, Casella, Alena, Diloretto, Daphne, Ginnell, Clara, Griffin, Katherine H., Bigot, Anne, Leach, J. Kent
Format: Article
Language:English
Subjects:
Alginates
Alginic acid
Growth factors
Hydrogels
Ionic interactions
Mesenchyme
Regeneration
Secretome
Sequestering
Spheroids
Stromal cells
Tissue engineering
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Summary:Mesenchymal Stromal Cells In article number 2101048 by J. Kent Leach and co‐workers, spheroids of mesenchymal stromal cells (MSCs) secrete high levels of relevant growth factors (GFs) for tissue regeneration. Sulfated alginate can sequester these GFs through ionic interactions, allowing increased therapeutic potency to invading cells. This paper investigates how MSC spheroidsecreted GFs are retained in sulfated alginate and their ability to influence cell function in vitro.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202170104