Antimicrobial and antibiofilm activity of GNP-Tannic Acid-Ag nanocomposite and their epoxy-based coatings

In order to deal with the challenge of biofilms and its associated infections, it is important to develop some efficient methodology which prevents the formation of biofilms over the surfaces. Herein, we have successfully developed an antibacterial and antibiofilm composite using non-toxic and hydro...

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Bibliographic Details
Published in:Progress in organic coatings 2021-10, Vol.159, p.106421, Article 106421
Main Authors: Singhal, Akshay V., Malwal, Deepika, Thiyagarajan, Shankar, Lahiri, Indranil
Format: Article
Language:English
Subjects:
Antibiofilm
Antibiotics
Antiinfectives and antibacterials
Antimicrobial
Biofilms
Coatings
Composite
Cytotoxicity
E coli
Efficiency
Glass substrates
Graphene
Graphene nanoplatelets
Hydrophobicity
Hydrothermal treatment
Hydroxyl groups
Nanocomposites
Nanomaterials
Raman spectroscopy
Silver
Tannic acid
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Summary:In order to deal with the challenge of biofilms and its associated infections, it is important to develop some efficient methodology which prevents the formation of biofilms over the surfaces. Herein, we have successfully developed an antibacterial and antibiofilm composite using non-toxic and hydrophobic nanomaterial, graphene nanoplatelets, via facile two step methodology including functionalization and subsequent hydrothermal treatment. The as-prepared composites were characterized using FE-SEM, FTIR and Raman spectroscopy to obtain morphological, compositional and structural details. In addition, the antibacterial efficiency of these composites was investigated against antibiotic resistant S. aureus and E. coli. Afterwards, graphene composite based epoxy coatings were prepared on glass substrate and tested for their antibiofilm efficiency against methicillin resistant S. aureus strain. The abundant presence of hydroxyl groups over the surface due to tannic acid, hydrophobicity of graphene and epoxy and remarkable antibacterial efficiency of tannic acid (TA), silver (Ag) and graphene synergistically enhance the antibiofilm efficiency of such coatings. This work presents a new strategy to develop a multifunctional coating and subsequently lessen the risk of biofilm assisted infections. [Display omitted]
ISSN:0300-9440
1873-331X
DOI:10.1016/j.porgcoat.2021.106421