Crosstalk between miRNA and PI3K/AKT/mTOR signaling pathway in cancer

Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most important proliferative signaling pathways with critical undeniable function in various aspects of cancer initiation/progression, including proliferation, apoptosis, metastasis, angiogenesi...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2021-11, Vol.285, p.119984, Article 119984
Main Authors: Akbarzadeh, Maryam, Mihanfar, Ainaz, Akbarzadeh, Shabnam, Yousefi, Bahman, Majidinia, Maryam
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Angiogenesis
Apoptosis
Cancer
Crosstalk
Drug resistance
Kinases
Metastases
Metastasis
MicroRNAs
miRNA
PI3K/AKT/mTOR
Rapamycin
Signal transduction
Signaling
TOR protein
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most important proliferative signaling pathways with critical undeniable function in various aspects of cancer initiation/progression, including proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. On the other hand, numerous genetic alterations in the key genes involved in the PI3K/AKT/mTOR signaling pathway have been identified in multiple solid and hematological tumors. In addition, accumulating recent evidences have demonstrated a reciprocal interaction between this signaling pathway and microRNAs, a large group of small non-coding RNAs. Therefore, in this review, it was attempted to discuss about the interaction between key components of PI3K/AKT/mTOR signaling pathway with various miRNAs and their importance in cancer biology.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2021.119984