Synthesis and Anticancer Activity of New Pyrimidine and Oxadiazole Acyclic Nucleoside Analogs and Thiazolopyrimidine Derivatives

A group of new substituted pyrimidine compounds, and their thiazolopyrimidines and 1,3,4-oxadiazolyl acyclic sugar derivatives have been synthesized as potential anti-cancer candidates. Oxadiazolyl-pyrimidine hybrid compounds have been synthesized by the reaction of thioacetohydrazide derivative wit...

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Bibliographic Details
Published in:Russian journal of general chemistry 2021-10, Vol.91 (10), p.2086-2094
Main Authors: Rahman, A. A. H. Abdel, Shaban, A. K. F., Nassar, I. F., Yousif, M. N. M., El-Kady, D. S., Awad, H. M., El-Sayed, W. A.
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Carbon disulfide
Care and treatment
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrazines
Hydrazones
Liver
Liver cancer
Nucleoside analogs
Nucleosides
Oxadiazoles
Pyrimidines
Side effects
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Summary:A group of new substituted pyrimidine compounds, and their thiazolopyrimidines and 1,3,4-oxadiazolyl acyclic sugar derivatives have been synthesized as potential anti-cancer candidates. Oxadiazolyl-pyrimidine hybrid compounds have been synthesized by the reaction of thioacetohydrazide derivative with carbon disulfide and heterocyclization of sugar hydrazones with acetic anhydride. The synthesized products have been studied for their anticancer activity against human liver carcinoma (HepG-2) and human normal retina pigmented epithelium (RPE-1). The synthesized sugar hydrazine of D-glucose, its 1,3,4-oxadiazole acyclic nucleoside and arylidine derivative demonstrate high selective anti-cancer activity against liver cell line without side effects on normal cells.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363221100261