Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats

The present study compared the effect of donepezil only and combination of donepezil and gallic acid on oxidative status and cholinesterase activity in the brain of Wistar rats administered AlCl 3 for 60 days. Twenty-eight rats (180 – 200 g) were arbitrarily distributed into four groups of seven ani...

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Bibliographic Details
Published in:Metabolic brain disease 2021-12, Vol.36 (8), p.2511-2519
Main Authors: Obafemi, Tajudeen O., Owolabi, Olutumise V., Omiyale, Benjamin O., Afolabi, Blessing A., Ojo, Oluwafemi A., Onasanya, Amos, Adu, Isaac A. I., Rotimi, Damilare
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Acids
Aluminum
Aluminum Chloride
Animals
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Butyrylcholinesterase - metabolism
Butyrylcholinesterase - pharmacology
Catalase
Cholinesterase
Distilled water
Donepezil
Donepezil - pharmacology
Gallic acid
Gallic Acid - pharmacology
Gallic Acid - therapeutic use
Lipid Peroxidation
Malondialdehyde
Metabolic Diseases
Neurology
Neurosciences
Neurotoxicity
Nitric oxide
Oncology
Oral administration
Original Article
Oxidative Stress
Rats
Rats, Wistar
Superoxide dismutase
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Summary:The present study compared the effect of donepezil only and combination of donepezil and gallic acid on oxidative status and cholinesterase activity in the brain of Wistar rats administered AlCl 3 for 60 days. Twenty-eight rats (180 – 200 g) were arbitrarily distributed into four groups of seven animals apiece. Group 1 served as normal control and received distilled water throughout the study. Group 2 animals received only AlCl 3 throughout the study while animals in groups 3 and 4 were administered donepezil only (10 mg/kg) and combination of donepezil (10 mg/kg) and gallic acid (50 mg/kg), respectively, in addition to AlCl 3 . Treatments were administered orally by gavage. At the end of the study, animals were sacrificed and activities of acetylcholinesterase, butyrylcholinesterase, superoxide dismutase (SOD) and catalase as well as levels of malondialdehyde (MDA), total thiol and nitric oxide (NO) were evaluated in the brain. Histopathological study was conducted on the hippocampus of experimental animals. Results showed that AlCl 3 significantly (p 
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-021-00749-w