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Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor
In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [ 68 Ga] GaCl 3 and thioglycolic acid (TGA) capped Gd-...
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Published in: | Journal of radioanalytical and nuclear chemistry 2021-12, Vol.330 (3), p.1137-1145 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [
68
Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [
68
Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [
68
Ga] GaCl
3
and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [
68
Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [
68
Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [
68
Ga] Ga@Gd-CdTe QDs were observed. |
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ISSN: | 0236-5731 1588-2780 |
DOI: | 10.1007/s10967-021-08058-3 |