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Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor

In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [ 68 Ga] GaCl 3 and thioglycolic acid (TGA) capped Gd-...

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Published in:Journal of radioanalytical and nuclear chemistry 2021-12, Vol.330 (3), p.1137-1145
Main Authors: Gharghani, Shima, Fazaeli, Yousef, Zare, Hakimeh, Feizi, Shahzad, Ashtari, Parviz, Shahedi, Zahra
Format: Article
Language:English
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Summary:In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [ 68 Ga] GaCl 3 and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [ 68 Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [ 68 Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [ 68 Ga] Ga@Gd-CdTe QDs were observed.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-021-08058-3