The prognostic value of the serum inflammatory biomarkers in patients with carotid atherosclerosis

20 % of ischemic stroke appear to originate from carotid artery atherosclerotic disease. Serum biomarkers reflecting the activity of atherosclerotic process and may help for estimate risk of acute cerebrovascular events. Several serum inflammatory markers have been proposed for risk assessment, but...

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Bibliographic Details
Published in:Eureka (Tallin) 2021-07 (4), p.26-33
Main Authors: Dubenko, Olga, Litovchenko, Tetyana, Anysienkova, Victoria, Nessonova, Maryna, Kovalenko, Liudmyla
Format: Article
Language:English
Subjects:
Asymptomatic
Atherosclerosis
Biomarkers
Stroke
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Summary:20 % of ischemic stroke appear to originate from carotid artery atherosclerotic disease. Serum biomarkers reflecting the activity of atherosclerotic process and may help for estimate risk of acute cerebrovascular events. Several serum inflammatory markers have been proposed for risk assessment, but their prognostic role less known. The aim of this study is to clarify the prognostic value of biomarkers of atherosclerosis lipoprotein-associated phospholipase A2 (Lp-PLA2) and E-selectin in patients with symptomatic and asymptomatic carotid stenosis. Materials and methods. The study involved 106 patients with atherosclerotic carotid stenosis >50 % (74 men and 32 women, mean age 62.6±0.9) from which 76 symptomatic (35 with acute ipsilateral atherothrombotic stroke and 41 after carotid endarterectomy) and 30 asymptomatic patients. The control group consisted of age- and sex-matched 20 healthy subjects. The level of serum Lp-PLA2 and E-selectin was determined using a commercially available enzyme-linked immunosorbent assay kit. Results. The level of Lp-PLA 2 was in general significantly higher (p
ISSN:2504-5660
2504-5679
DOI:10.21303/2504-5679.2021.001969