Aging and its treatment with vitamin C: a comprehensive mechanistic review

Aging and age-related disorders have become one of the prominent issue of world. Oxidative stress due to overproduction of reactive oxygen species is the most significant cause of aging. The aim of literature compilation was to elucidate the therapeutic effect of vitamin C against oxidative stress....

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Bibliographic Details
Published in:Molecular biology reports 2021-12, Vol.48 (12), p.8141-8153
Main Authors: Mumtaz, Shumaila, Ali, Shaukat, Tahir, Hafiz Muhammad, Kazmi, Syed Akif Raza, Shakir, Hafiz Abdullah, Mughal, Tafail Akbar, Mumtaz, Samaira, Summer, Muhammad, Farooq, Muhammad Adeel
Format: Article
Language:English
Subjects:
Aging
Aging - drug effects
Aging - physiology
Animal Anatomy
Animal Biochemistry
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Ascorbic acid
Ascorbic Acid - metabolism
Ascorbic Acid - pharmacology
Biomedical and Life Sciences
Chromatin
Free Radical Scavengers - pharmacology
Histology
Humans
Inflammation
Life Sciences
Morphology
Oxidants
Oxidative stress
Oxidative Stress - physiology
Reactive Oxygen Species
Review
Telomeres
Vitamin C
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Summary:Aging and age-related disorders have become one of the prominent issue of world. Oxidative stress due to overproduction of reactive oxygen species is the most significant cause of aging. The aim of literature compilation was to elucidate the therapeutic effect of vitamin C against oxidative stress. Various mediators with anti-inflammatory and anti-oxidant properties might be probable competitors of vitamin C for the improvement of innovative anti-aging treatments. More attention has been paid to vitamin C due to its anti-oxidant property and potentially beneficial biological activities for inhibiting aging.Vitamin C acts as an antioxidant agent and free radical scavenger that can protect the cell from oxidative stress, disorganization of chromatin, telomere attrition, and prolong the lifetime. This review emphasizes mechanism of aging and various biomarkers that are directly related to aging and also focuses on the therapeutic aspect of vitamin C against oxidative stress and age-related disorders.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06781-4