Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids

A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp3)–H bonds in good yields from commercially available alkyl carboxylic...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2021-11, Vol.8 (23), p.6603-6608
Main Authors: Ke-Jin Jiao, Ma, Cong, Liu, Dong, Qiu, Hui, Cheng, Bin, Tian-Sheng Mei
Format: Article
Language:English
Subjects:
Acylation
Bromides
Carboxylic acids
Cross coupling
Electrochemistry
Functional groups
Halides
Ketones
Nickel
Organic chemistry
Relay
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Summary:A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp3)–H bonds in good yields from commercially available alkyl carboxylic acids, thus providing an alternative strategy for the synthesis of dialkyl ketones. Various functional groups are tolerated under mild reaction conditions.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01219c