Nickel-catalyzed cascade carbonylative synthesis of N-benzoyl indoles from 2-nitroalkynes and aryl iodides

A nickel-catalyzed carbonylative cyclization of 2-nitroalkynes and aryl iodides has been developed for the expedite construction of N-benzoyl indole scaffolds. Using Co2(CO)8 as the CO source, this cascade reaction proceeded with high efficiency to give a variety of N-benzoyl indoles in moderate to...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2021-11, Vol.8 (23), p.6541-6545
Main Authors: Yao, Lingyun, Ying, Jun, Xiao-Feng, Wu
Format: Article
Language:English
Subjects:
Aromatic compounds
Carbon dioxide
Carbon monoxide
Carbonyls
Cascade chemical reactions
Chemical synthesis
Indoles
Iodides
Nickel
Organic chemistry
Reaction mechanisms
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Summary:A nickel-catalyzed carbonylative cyclization of 2-nitroalkynes and aryl iodides has been developed for the expedite construction of N-benzoyl indole scaffolds. Using Co2(CO)8 as the CO source, this cascade reaction proceeded with high efficiency to give a variety of N-benzoyl indoles in moderate to high yields. Control experiments were performed as well to gain a better understanding of the reaction mechanism.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo01284c