Construction of Si‐Stereogenic Silanes through C−H Activation Approach

The asymmetric synthesis of Si‐stereogenic silanes has attracted great attention due to the increasing values of Si‐containing functional molecules in synthetic chemistry, medicinal chemistry, and material chemistry. Merging organosilicon chemistry with transition‐metal‐catalyzed C−H approach has le...

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Bibliographic Details
Published in:European journal of organic chemistry 2021-11, Vol.2021 (44), p.6006-6014
Main Authors: Zheng, Long, Nie, Xiao‐Xue, Wu, Yichen, Wang, Peng
Format: Article
Language:English
Subjects:
Asymmetric
C−H Activation
Organosilanes
Si-stereogenic
Silanes
Silylation
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Summary:The asymmetric synthesis of Si‐stereogenic silanes has attracted great attention due to the increasing values of Si‐containing functional molecules in synthetic chemistry, medicinal chemistry, and material chemistry. Merging organosilicon chemistry with transition‐metal‐catalyzed C−H approach has led to rich sets of new reactions holding great synthetic values. This Minireview aims to summarize the advances in the construction of Si‐stereogenic silanes through the transition‐metal‐catalyzed C−H activation approach. The preparation of chiral Si‐stereogenic silanes, a class of functional molecules with increasing values in synthetic chemistry, medicinal chemistry, and material chemistry, via transition‐metal‐catalyzed C−H activation approach is an elegant and attractive manner, in short steps from simple starting materials. This Minireview summarizes the advances in construction of Si‐stereogenic silanes by using this approach as well as future perspectives.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202101084