Synthesis, characterization, in vitro antimicrobial and anticancer activity of metal(II) complexes of Schiff base-derived from 3-formyl-2-mercaptoquinoline and thiosemicarbazide

2-Mercaptoquinoline thiosemicarbzone metal(II) complexes of the type [M(L) 2 ], (M = Co, Ni, Cu & Zn) were synthesized from the reaction of 2-((mercaptoquinolin-3-yl)methylene)hydrazinecarbothioamide Schiff base ligand (HL) with metal(II) chlorides. The synthesized compounds were characterized b...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2021-12, Vol.196 (12), p.1078-1083
Main Authors: Gokulnath, Ganesan, Manikandan, Rajendran, Anitha, Panneerselvam, Umarani, Chinnusamy
Format: Article
Language:English
Subjects:
2-Mercaptoquinoline
anticancer activity
Anticancer properties
Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Chemical analysis
Chemical synthesis
Coordination compounds
Imines
Infrared analysis
Ligands
metal(II) complexes
Nickel
NMR
Nuclear magnetic resonance
thiosemicarbazone
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Summary:2-Mercaptoquinoline thiosemicarbzone metal(II) complexes of the type [M(L) 2 ], (M = Co, Ni, Cu & Zn) were synthesized from the reaction of 2-((mercaptoquinolin-3-yl)methylene)hydrazinecarbothioamide Schiff base ligand (HL) with metal(II) chlorides. The synthesized compounds were characterized by elemental analysis, FT-IR, 1 H NMR, 13 C NMR, ESR and ESI-mass spectral studies. The analytical and spectral data revealed that Schiff base ligand is coordinated with the metal center, via dissociation of the one acidic proton, as a monoanionic tridentate SNS donor and that metal(II) ions adopt octahedral coordination. The antimicrobial activity of the ligand and metal(II) complexes was studied against bacterial strains and fungal stains. Furthermore, the cytotoxic properties of ligand and complexes were studied against MCF-7 cell line.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2021.1966630