The NHLBI Study on Long-ter M O U tcomes after the Multisystem I nflammatory S yndrome I n C hildren (MUSIC): Design and Objectives

BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which a...

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Published in:The American heart journal 2022-01, Vol.243, p.43
Main Authors: Truong, Dongngan T, Trachtenberg, Felicia L, Pearson, Gail D, Dionne, Audrey, Elias, Matthew D, Friedman, Kevin, Hayes, Kerri H, Mahony, Lynn, McCrindle, Brian W, Oster, Matthew E, Pemberton, Victoria, Powell, Andrew J, Russell, Mark W, Shekerdemian, Lara S, Son, Mary Beth, Taylor, Michael, Newburger, Jane W, Giglia, Therese M, McHugh, Kimberly E, Atz, Andrew M, Pletzer, Scott A, Lang, Sean M, Payne, R Mark, Patel, Jyoti K, Pignatelli, Ricardo H, Sexson, Kristen, Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R, Farooqi, Kanwal M, Shakti, Divya, Parnell, Aimee S, Osakwe, Onyekachukwu J, Sykes, Michelle C, Morgan, Lerraughn, Owada, Carl Y, sha, Daniel, Carr, Michael R, Watanabe, Kae, Portman, Michael A, Dummer, Kristen B, Burns, Jane C, Tremoulet, Adriana H, Sharma, Kavita, Pei-Ni Jone, Michelle Hite Heather Heizer, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L, Szmuszkovicz, Jacqueline R, Wong, Pierre C, Cheng, Andrew L, Votava-Smith, Jodie K, Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K, Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T, Muniz, Juan Carlos G, Li, Jennifer S, Campbell, Michael Jay, Handler, Stephanie S, J Ryan Shea, Hoffman, Timothy M, Franklin, Wayne J, Sabati, Arash A, Nowlen, Todd T, Chrisant, Maryanne
Format: Article
Language:English
Subjects:
Adjudication
Aneurysms
Children
Chronic fatigue syndrome
Complications
Coronary artery
Coronary artery disease
Coronaviruses
COVID-19
Disease control
Genetic screening
Inflammation
Long-term effects
Magnetic resonance imaging
Medical imaging
Multisystem inflammatory syndrome in children
Patients
Public health
Regression analysis
Statistical analysis
Veins & arteries
Ventricle
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container_title The American heart journal
container_volume 243
creator Truong, Dongngan T
Trachtenberg, Felicia L
Pearson, Gail D
Dionne, Audrey
Elias, Matthew D
Friedman, Kevin
Hayes, Kerri H
Mahony, Lynn
McCrindle, Brian W
Oster, Matthew E
Pemberton, Victoria
Powell, Andrew J
Russell, Mark W
Shekerdemian, Lara S
Son, Mary Beth
Taylor, Michael
Newburger, Jane W
Elias, Matthew D
Giglia, Therese M
McHugh, Kimberly E
Atz, Andrew M
Pletzer, Scott A
Lang, Sean M
Payne, R Mark
Patel, Jyoti K
Oster, Matthew E
Pignatelli, Ricardo H
Sexson, Kristen
Lam, Christopher
Dragulescu, Andreea
Young, Rae SM
Gamulka, Beth
Krishnan, Anita
Anderson, Brett R
Farooqi, Kanwal M
Shakti, Divya
Parnell, Aimee S
Osakwe, Onyekachukwu J
Sykes, Michelle C
Morgan, Lerraughn
Owada, Carl Y
sha, Daniel
Carr, Michael R
Watanabe, Kae
Portman, Michael A
Dummer, Kristen B
Burns, Jane C
Tremoulet, Adriana H
Sharma, Kavita
Pei-Ni Jone
Michelle Hite Heather Heizer
Hasbani, Keren
Srivastava, Shubhika
Mitchell, Elizabeth C
Hebson, Camden L
Szmuszkovicz, Jacqueline R
Wong, Pierre C
Cheng, Andrew L
Votava-Smith, Jodie K
Wang, Shuo
Mohandas, Sindhu
Singh, Gautam K
Aggarwal, Sanjeev
Sanil, Yamuna
Bradford, Tamara T
Muniz, Juan Carlos G
Li, Jennifer S
Campbell, Michael Jay
Handler, Stephanie S
J Ryan Shea
Hoffman, Timothy M
Franklin, Wayne J
Sabati, Arash A
Nowlen, Todd T
Chrisant, Maryanne
description BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients
doi_str_mv 10.1016/j.ahj.2021.08.003
format article
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The study will collect detailed hospital and follow-up data for up to 5 years, and optional genetic testing. Cardiac imaging at specific time points includes standardized echocardiographic assessment (all participants) and cardiac magnetic resonance imaging (CMR) in those with left ventricular ejection fraction (LVEF) &lt;45% during the acute illness. The primary outcomes are the worst LVEF and the highest coronary artery z-score of the left anterior descending or right coronary artery. Other outcomes include occurrence and course of non-cardiac organ dysfunction, inflammation, and major medical events. Independent adjudication of cases will classify participants as definite, possible, or not MIS-C. Analysis of the outcomes will include descriptive statistics and regression analysis with stratification by definite or possible MIS-C. The MUSIC study will provide phenotypic data to support basic and translational research studies.ConclusionThe MUSIC study, with the largest cohort of MIS-C patients and the longest follow-up period to date, will make an important contribution to our understanding of the acute cardiac and non-cardiac manifestations of MIS-C and the long-term effects of this public health emergency.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2021.08.003</identifier><language>eng</language><publisher>Philadelphia: Elsevier Limited</publisher><subject>Adjudication ; Aneurysms ; Children ; Chronic fatigue syndrome ; Complications ; Coronary artery ; Coronary artery disease ; Coronaviruses ; COVID-19 ; Disease control ; Genetic screening ; Inflammation ; Long-term effects ; Magnetic resonance imaging ; Medical imaging ; Multisystem inflammatory syndrome in children ; Patients ; Public health ; Regression analysis ; Statistical analysis ; Veins &amp; arteries ; Ventricle</subject><ispartof>The American heart journal, 2022-01, Vol.243, p.43</ispartof><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Truong, Dongngan T</creatorcontrib><creatorcontrib>Trachtenberg, Felicia L</creatorcontrib><creatorcontrib>Pearson, Gail D</creatorcontrib><creatorcontrib>Dionne, Audrey</creatorcontrib><creatorcontrib>Elias, Matthew D</creatorcontrib><creatorcontrib>Friedman, Kevin</creatorcontrib><creatorcontrib>Hayes, Kerri H</creatorcontrib><creatorcontrib>Mahony, Lynn</creatorcontrib><creatorcontrib>McCrindle, Brian W</creatorcontrib><creatorcontrib>Oster, Matthew E</creatorcontrib><creatorcontrib>Pemberton, Victoria</creatorcontrib><creatorcontrib>Powell, Andrew J</creatorcontrib><creatorcontrib>Russell, Mark W</creatorcontrib><creatorcontrib>Shekerdemian, Lara S</creatorcontrib><creatorcontrib>Son, Mary Beth</creatorcontrib><creatorcontrib>Taylor, Michael</creatorcontrib><creatorcontrib>Newburger, Jane W</creatorcontrib><creatorcontrib>Elias, Matthew D</creatorcontrib><creatorcontrib>Giglia, Therese M</creatorcontrib><creatorcontrib>McHugh, Kimberly E</creatorcontrib><creatorcontrib>Atz, Andrew M</creatorcontrib><creatorcontrib>Pletzer, Scott A</creatorcontrib><creatorcontrib>Lang, Sean M</creatorcontrib><creatorcontrib>Payne, R Mark</creatorcontrib><creatorcontrib>Patel, Jyoti K</creatorcontrib><creatorcontrib>Oster, Matthew E</creatorcontrib><creatorcontrib>Pignatelli, Ricardo H</creatorcontrib><creatorcontrib>Sexson, Kristen</creatorcontrib><creatorcontrib>Lam, Christopher</creatorcontrib><creatorcontrib>Dragulescu, Andreea</creatorcontrib><creatorcontrib>Young, Rae SM</creatorcontrib><creatorcontrib>Gamulka, Beth</creatorcontrib><creatorcontrib>Krishnan, Anita</creatorcontrib><creatorcontrib>Anderson, Brett R</creatorcontrib><creatorcontrib>Farooqi, Kanwal M</creatorcontrib><creatorcontrib>Shakti, Divya</creatorcontrib><creatorcontrib>Parnell, Aimee S</creatorcontrib><creatorcontrib>Osakwe, Onyekachukwu J</creatorcontrib><creatorcontrib>Sykes, Michelle C</creatorcontrib><creatorcontrib>Morgan, Lerraughn</creatorcontrib><creatorcontrib>Owada, Carl Y</creatorcontrib><creatorcontrib>sha, Daniel</creatorcontrib><creatorcontrib>Carr, Michael R</creatorcontrib><creatorcontrib>Watanabe, Kae</creatorcontrib><creatorcontrib>Portman, Michael A</creatorcontrib><creatorcontrib>Dummer, Kristen B</creatorcontrib><creatorcontrib>Burns, Jane C</creatorcontrib><creatorcontrib>Tremoulet, Adriana H</creatorcontrib><creatorcontrib>Sharma, Kavita</creatorcontrib><creatorcontrib>Pei-Ni Jone</creatorcontrib><creatorcontrib>Michelle Hite Heather Heizer</creatorcontrib><creatorcontrib>Hasbani, Keren</creatorcontrib><creatorcontrib>Srivastava, Shubhika</creatorcontrib><creatorcontrib>Mitchell, Elizabeth C</creatorcontrib><creatorcontrib>Hebson, Camden L</creatorcontrib><creatorcontrib>Szmuszkovicz, Jacqueline R</creatorcontrib><creatorcontrib>Wong, Pierre C</creatorcontrib><creatorcontrib>Cheng, Andrew L</creatorcontrib><creatorcontrib>Votava-Smith, Jodie K</creatorcontrib><creatorcontrib>Wang, Shuo</creatorcontrib><creatorcontrib>Mohandas, Sindhu</creatorcontrib><creatorcontrib>Singh, Gautam K</creatorcontrib><creatorcontrib>Aggarwal, Sanjeev</creatorcontrib><creatorcontrib>Sanil, Yamuna</creatorcontrib><creatorcontrib>Bradford, Tamara T</creatorcontrib><creatorcontrib>Muniz, Juan Carlos G</creatorcontrib><creatorcontrib>Li, Jennifer S</creatorcontrib><creatorcontrib>Campbell, Michael Jay</creatorcontrib><creatorcontrib>Handler, Stephanie S</creatorcontrib><creatorcontrib>J Ryan Shea</creatorcontrib><creatorcontrib>Hoffman, Timothy M</creatorcontrib><creatorcontrib>Franklin, Wayne J</creatorcontrib><creatorcontrib>Sabati, Arash A</creatorcontrib><creatorcontrib>Nowlen, Todd T</creatorcontrib><creatorcontrib>Chrisant, Maryanne</creatorcontrib><title>The NHLBI Study on Long-ter M O U tcomes after the Multisystem I nflammatory S yndrome I n C hildren (MUSIC): Design and Objectives</title><title>The American heart journal</title><description>BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients &lt;21 years old who meet the Centers for Disease Control and Prevention case definition of MIS-C across multiple North American centers over 2 years. The study will collect detailed hospital and follow-up data for up to 5 years, and optional genetic testing. Cardiac imaging at specific time points includes standardized echocardiographic assessment (all participants) and cardiac magnetic resonance imaging (CMR) in those with left ventricular ejection fraction (LVEF) &lt;45% during the acute illness. The primary outcomes are the worst LVEF and the highest coronary artery z-score of the left anterior descending or right coronary artery. Other outcomes include occurrence and course of non-cardiac organ dysfunction, inflammation, and major medical events. Independent adjudication of cases will classify participants as definite, possible, or not MIS-C. Analysis of the outcomes will include descriptive statistics and regression analysis with stratification by definite or possible MIS-C. The MUSIC study will provide phenotypic data to support basic and translational research studies.ConclusionThe MUSIC study, with the largest cohort of MIS-C patients and the longest follow-up period to date, will make an important contribution to our understanding of the acute cardiac and non-cardiac manifestations of MIS-C and the long-term effects of this public health emergency.</description><subject>Adjudication</subject><subject>Aneurysms</subject><subject>Children</subject><subject>Chronic fatigue syndrome</subject><subject>Complications</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease control</subject><subject>Genetic screening</subject><subject>Inflammation</subject><subject>Long-term effects</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Multisystem inflammatory syndrome in children</subject><subject>Patients</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Veins &amp; 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Trachtenberg, Felicia L ; Pearson, Gail D ; Dionne, Audrey ; Elias, Matthew D ; Friedman, Kevin ; Hayes, Kerri H ; Mahony, Lynn ; McCrindle, Brian W ; Oster, Matthew E ; Pemberton, Victoria ; Powell, Andrew J ; Russell, Mark W ; Shekerdemian, Lara S ; Son, Mary Beth ; Taylor, Michael ; Newburger, Jane W ; Elias, Matthew D ; Giglia, Therese M ; McHugh, Kimberly E ; Atz, Andrew M ; Pletzer, Scott A ; Lang, Sean M ; Payne, R Mark ; Patel, Jyoti K ; Oster, Matthew E ; Pignatelli, Ricardo H ; Sexson, Kristen ; Lam, Christopher ; Dragulescu, Andreea ; Young, Rae SM ; Gamulka, Beth ; Krishnan, Anita ; Anderson, Brett R ; Farooqi, Kanwal M ; Shakti, Divya ; Parnell, Aimee S ; Osakwe, Onyekachukwu J ; Sykes, Michelle C ; Morgan, Lerraughn ; Owada, Carl Y ; sha, Daniel ; Carr, Michael R ; Watanabe, Kae ; Portman, Michael A ; Dummer, Kristen B ; Burns, Jane C ; Tremoulet, Adriana H ; Sharma, Kavita ; Pei-Ni Jone ; Michelle Hite Heather Heizer ; Hasbani, Keren ; Srivastava, Shubhika ; Mitchell, Elizabeth C ; Hebson, Camden L ; Szmuszkovicz, Jacqueline R ; Wong, Pierre C ; Cheng, Andrew L ; Votava-Smith, Jodie K ; Wang, Shuo ; Mohandas, Sindhu ; Singh, Gautam K ; Aggarwal, Sanjeev ; Sanil, Yamuna ; Bradford, Tamara T ; Muniz, Juan Carlos G ; Li, Jennifer S ; Campbell, Michael Jay ; Handler, Stephanie S ; J Ryan Shea ; Hoffman, Timothy M ; Franklin, Wayne J ; Sabati, Arash A ; Nowlen, Todd T ; Chrisant, Maryanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_26029918203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adjudication</topic><topic>Aneurysms</topic><topic>Children</topic><topic>Chronic fatigue syndrome</topic><topic>Complications</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Disease control</topic><topic>Genetic screening</topic><topic>Inflammation</topic><topic>Long-term effects</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Multisystem inflammatory syndrome in children</topic><topic>Patients</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Veins &amp; arteries</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Truong, Dongngan T</creatorcontrib><creatorcontrib>Trachtenberg, Felicia L</creatorcontrib><creatorcontrib>Pearson, Gail D</creatorcontrib><creatorcontrib>Dionne, Audrey</creatorcontrib><creatorcontrib>Elias, Matthew D</creatorcontrib><creatorcontrib>Friedman, Kevin</creatorcontrib><creatorcontrib>Hayes, Kerri H</creatorcontrib><creatorcontrib>Mahony, Lynn</creatorcontrib><creatorcontrib>McCrindle, Brian W</creatorcontrib><creatorcontrib>Oster, Matthew E</creatorcontrib><creatorcontrib>Pemberton, Victoria</creatorcontrib><creatorcontrib>Powell, Andrew J</creatorcontrib><creatorcontrib>Russell, Mark W</creatorcontrib><creatorcontrib>Shekerdemian, Lara S</creatorcontrib><creatorcontrib>Son, Mary Beth</creatorcontrib><creatorcontrib>Taylor, Michael</creatorcontrib><creatorcontrib>Newburger, Jane W</creatorcontrib><creatorcontrib>Elias, Matthew D</creatorcontrib><creatorcontrib>Giglia, Therese M</creatorcontrib><creatorcontrib>McHugh, Kimberly E</creatorcontrib><creatorcontrib>Atz, Andrew M</creatorcontrib><creatorcontrib>Pletzer, Scott A</creatorcontrib><creatorcontrib>Lang, Sean M</creatorcontrib><creatorcontrib>Payne, R Mark</creatorcontrib><creatorcontrib>Patel, Jyoti K</creatorcontrib><creatorcontrib>Oster, Matthew E</creatorcontrib><creatorcontrib>Pignatelli, Ricardo H</creatorcontrib><creatorcontrib>Sexson, Kristen</creatorcontrib><creatorcontrib>Lam, Christopher</creatorcontrib><creatorcontrib>Dragulescu, Andreea</creatorcontrib><creatorcontrib>Young, Rae SM</creatorcontrib><creatorcontrib>Gamulka, Beth</creatorcontrib><creatorcontrib>Krishnan, Anita</creatorcontrib><creatorcontrib>Anderson, Brett R</creatorcontrib><creatorcontrib>Farooqi, Kanwal M</creatorcontrib><creatorcontrib>Shakti, Divya</creatorcontrib><creatorcontrib>Parnell, Aimee S</creatorcontrib><creatorcontrib>Osakwe, Onyekachukwu J</creatorcontrib><creatorcontrib>Sykes, Michelle C</creatorcontrib><creatorcontrib>Morgan, Lerraughn</creatorcontrib><creatorcontrib>Owada, Carl Y</creatorcontrib><creatorcontrib>sha, Daniel</creatorcontrib><creatorcontrib>Carr, Michael R</creatorcontrib><creatorcontrib>Watanabe, Kae</creatorcontrib><creatorcontrib>Portman, Michael A</creatorcontrib><creatorcontrib>Dummer, Kristen B</creatorcontrib><creatorcontrib>Burns, Jane C</creatorcontrib><creatorcontrib>Tremoulet, Adriana H</creatorcontrib><creatorcontrib>Sharma, Kavita</creatorcontrib><creatorcontrib>Pei-Ni Jone</creatorcontrib><creatorcontrib>Michelle Hite Heather Heizer</creatorcontrib><creatorcontrib>Hasbani, Keren</creatorcontrib><creatorcontrib>Srivastava, Shubhika</creatorcontrib><creatorcontrib>Mitchell, Elizabeth C</creatorcontrib><creatorcontrib>Hebson, Camden L</creatorcontrib><creatorcontrib>Szmuszkovicz, Jacqueline R</creatorcontrib><creatorcontrib>Wong, Pierre C</creatorcontrib><creatorcontrib>Cheng, Andrew L</creatorcontrib><creatorcontrib>Votava-Smith, Jodie K</creatorcontrib><creatorcontrib>Wang, Shuo</creatorcontrib><creatorcontrib>Mohandas, Sindhu</creatorcontrib><creatorcontrib>Singh, Gautam K</creatorcontrib><creatorcontrib>Aggarwal, Sanjeev</creatorcontrib><creatorcontrib>Sanil, Yamuna</creatorcontrib><creatorcontrib>Bradford, Tamara T</creatorcontrib><creatorcontrib>Muniz, Juan Carlos G</creatorcontrib><creatorcontrib>Li, Jennifer S</creatorcontrib><creatorcontrib>Campbell, Michael Jay</creatorcontrib><creatorcontrib>Handler, Stephanie S</creatorcontrib><creatorcontrib>J Ryan Shea</creatorcontrib><creatorcontrib>Hoffman, Timothy M</creatorcontrib><creatorcontrib>Franklin, Wayne J</creatorcontrib><creatorcontrib>Sabati, Arash A</creatorcontrib><creatorcontrib>Nowlen, Todd T</creatorcontrib><creatorcontrib>Chrisant, Maryanne</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest Medical &amp; Health Databases)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Health Management Database (Proquest)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Truong, Dongngan T</au><au>Trachtenberg, Felicia L</au><au>Pearson, Gail D</au><au>Dionne, Audrey</au><au>Elias, Matthew D</au><au>Friedman, Kevin</au><au>Hayes, Kerri H</au><au>Mahony, Lynn</au><au>McCrindle, Brian W</au><au>Oster, Matthew E</au><au>Pemberton, Victoria</au><au>Powell, Andrew J</au><au>Russell, Mark W</au><au>Shekerdemian, Lara S</au><au>Son, Mary Beth</au><au>Taylor, Michael</au><au>Newburger, Jane W</au><au>Elias, Matthew D</au><au>Giglia, Therese M</au><au>McHugh, Kimberly E</au><au>Atz, Andrew M</au><au>Pletzer, Scott A</au><au>Lang, Sean M</au><au>Payne, R Mark</au><au>Patel, Jyoti K</au><au>Oster, Matthew E</au><au>Pignatelli, Ricardo H</au><au>Sexson, Kristen</au><au>Lam, Christopher</au><au>Dragulescu, Andreea</au><au>Young, Rae SM</au><au>Gamulka, Beth</au><au>Krishnan, Anita</au><au>Anderson, Brett R</au><au>Farooqi, Kanwal M</au><au>Shakti, Divya</au><au>Parnell, Aimee S</au><au>Osakwe, Onyekachukwu J</au><au>Sykes, Michelle C</au><au>Morgan, Lerraughn</au><au>Owada, Carl Y</au><au>sha, Daniel</au><au>Carr, Michael R</au><au>Watanabe, Kae</au><au>Portman, Michael A</au><au>Dummer, Kristen B</au><au>Burns, Jane C</au><au>Tremoulet, Adriana H</au><au>Sharma, Kavita</au><au>Pei-Ni Jone</au><au>Michelle Hite Heather Heizer</au><au>Hasbani, Keren</au><au>Srivastava, Shubhika</au><au>Mitchell, Elizabeth C</au><au>Hebson, Camden L</au><au>Szmuszkovicz, Jacqueline R</au><au>Wong, Pierre C</au><au>Cheng, Andrew L</au><au>Votava-Smith, Jodie K</au><au>Wang, Shuo</au><au>Mohandas, Sindhu</au><au>Singh, Gautam K</au><au>Aggarwal, Sanjeev</au><au>Sanil, Yamuna</au><au>Bradford, Tamara T</au><au>Muniz, Juan Carlos G</au><au>Li, Jennifer S</au><au>Campbell, Michael Jay</au><au>Handler, Stephanie S</au><au>J Ryan Shea</au><au>Hoffman, Timothy M</au><au>Franklin, Wayne J</au><au>Sabati, Arash A</au><au>Nowlen, Todd T</au><au>Chrisant, Maryanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The NHLBI Study on Long-ter M O U tcomes after the Multisystem I nflammatory S yndrome I n C hildren (MUSIC): Design and Objectives</atitle><jtitle>The American heart journal</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>243</volume><spage>43</spage><pages>43-</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients &lt;21 years old who meet the Centers for Disease Control and Prevention case definition of MIS-C across multiple North American centers over 2 years. The study will collect detailed hospital and follow-up data for up to 5 years, and optional genetic testing. Cardiac imaging at specific time points includes standardized echocardiographic assessment (all participants) and cardiac magnetic resonance imaging (CMR) in those with left ventricular ejection fraction (LVEF) &lt;45% during the acute illness. The primary outcomes are the worst LVEF and the highest coronary artery z-score of the left anterior descending or right coronary artery. Other outcomes include occurrence and course of non-cardiac organ dysfunction, inflammation, and major medical events. Independent adjudication of cases will classify participants as definite, possible, or not MIS-C. Analysis of the outcomes will include descriptive statistics and regression analysis with stratification by definite or possible MIS-C. The MUSIC study will provide phenotypic data to support basic and translational research studies.ConclusionThe MUSIC study, with the largest cohort of MIS-C patients and the longest follow-up period to date, will make an important contribution to our understanding of the acute cardiac and non-cardiac manifestations of MIS-C and the long-term effects of this public health emergency.</abstract><cop>Philadelphia</cop><pub>Elsevier Limited</pub><doi>10.1016/j.ahj.2021.08.003</doi></addata></record>
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source ScienceDirect Freedom Collection 2022-2024
subjects Adjudication
Aneurysms
Children
Chronic fatigue syndrome
Complications
Coronary artery
Coronary artery disease
Coronaviruses
COVID-19
Disease control
Genetic screening
Inflammation
Long-term effects
Magnetic resonance imaging
Medical imaging
Multisystem inflammatory syndrome in children
Patients
Public health
Regression analysis
Statistical analysis
Veins & arteries
Ventricle
title The NHLBI Study on Long-ter M O U tcomes after the Multisystem I nflammatory S yndrome I n C hildren (MUSIC): Design and Objectives
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