Neuroimaging Functional Magnetic Resonance Imaging Task‐Based Dorsolateral Prefrontal Cortex Activation Following 12Weeks of Cosmos caudatus Supplementation Among Older Adults With Mild Cognitive Impairment

BackgroundCosmos caudatus (CC) is traditional Asian vegetable, commonly consumed among the Southeast Asian population. It has been reported to be high in flavonoids and might potentially improve brain activity among older adults with mild cognitive impairment (MCI). The effect of CC in brain activat...

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Published in:Journal of magnetic resonance imaging 2021-12, Vol.54 (6), p.1804-1818
Main Authors: Yee Xing You, Shahar, Suzana, Mazlyfarina Mohamad, Rajab, Nor Fadilah, Haron, Hasnah, Normah Che Din, Hamzaini Abdul Hamid
Format: Article
Language:English
Subjects:
Adults
Brain
Brain mapping
Brodmann's area
Chi-square test
Cognitive ability
Color
Cortex (cingulate)
Cosmos
Cosmos caudatus
Field strength
Flavonoids
Functional magnetic resonance imaging
Impairment
Magnetic resonance imaging
Maltodextrin
Medical imaging
Neuroimaging
Normality
Older people
Placebos
Prefrontal cortex
Resonance
Short term memory
Statistical analysis
Statistical tests
Supplements
Variance analysis
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Summary:BackgroundCosmos caudatus (CC) is traditional Asian vegetable, commonly consumed among the Southeast Asian population. It has been reported to be high in flavonoids and might potentially improve brain activity among older adults with mild cognitive impairment (MCI). The effect of CC in brain activation improvement using neuroimaging is yet to be discovered.PurposeTo investigate the effects of CC supplement on brain activity using functional magnetic resonance imaging (fMRI) among older adults with MCI.Study typeProspective, randomized, double‐blind, placebo‐controlled trial.Population/subjectsTwenty older adults with mild cognitive impairment (60–75 years old), 14 of them (70%) were female subjects.Field strength/sequenceA 3.0‐T, T1‐weighted anatomical images, T2*‐weighted imaging data, A single shot, gradient echo‐echo planar imaging (EPI) sequence.AssessmentAll subjects were asked to consume two 500 mg capsules of either CC supplement or placebo (maltodextrin) daily for 12 weeks. Cognitive function was measured using validated neuropsychological tests (i.e. Mini‐mental State Examination and Digit Span) and task‐based fMRI (N‐back and Stroop Color Word Test) at baseline and 12th week. Brodmann's area 9, 46 and anterior cingulate cortex were selected as the regions of interest to define dorsolateral prefrontal cortex (DLPFC) in fMRI analysis.Statistical testsNormality test was performed with the Shapiro–Wilk test. Two‐way repeated ANOVA determined the intervention effects of the CC supplementation on brain activity after adjustments for covariates. Significance level at P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.27762