Synthesis of a sustainable heterogeneous catalyst, titanium dioxide‐loaded hydroxyapatite for functionalised chromen‐dihydropyridines under green conditions

We have described the synthesis of composite materials with different titanium dioxide loading on hydroxyapatite (TiO2/HAp). Their structural properties and morphologies were established by powder X‐ray diffraction (p‐XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), transmissi...

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Bibliographic Details
Published in:Applied organometallic chemistry 2021-12, Vol.35 (12), p.n/a
Main Authors: Madhavi, Challa, Ganja, Himavathi, Kerru, Nagaraju, Maddila, Suresh, Jonnalagadda, Sreekantha B.
Format: Article
Language:English
Subjects:
Amines
Catalysts
Catalytic activity
Chemical synthesis
Chemistry
chromen‐dihydropyridines
Composite materials
Electron microscopy
Ethanol
Fourier transforms
heterogeneous catalysis
Hydroxyapatite
Infrared analysis
Malononitrile
Microscopy
Morphology
multicomponent reaction
Protective coatings
rapid synthesis
Reaction time
Room temperature
TiO2/HAp
Titanium
Titanium dioxide
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Summary:We have described the synthesis of composite materials with different titanium dioxide loading on hydroxyapatite (TiO2/HAp). Their structural properties and morphologies were established by powder X‐ray diffraction (p‐XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET), transmission electron microscopy (TEM) and Fourier transform infrared (FT‐IR) analyses. The catalytic efficacy of the as‐prepared composite materials was explored to synthesise novel 4‐oxo‐chromen‐dihydropyridine derivatives by the four‐component reaction. The one‐pot fusion in ethanol medium involved chromene‐3‐carbaldehyde, dimethyl acetylenedicarboxylate, malononitrile and different aromatic and heteroaryl amines. The method provided impressive yields (92–97%) of the target products in a short reaction time (
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.6442