Low-molecular components of colostrum as a regulator of the organism redox-system and biological antidote

• Published in: Eureka, Life Sciences Life Sciences, 2021-04 (2), p.56-64
• Main Authors: Ivanov, Ievgen, Kozheshkurt, Valentyn, Bozhkov, Anatoly, Goltvjansky, Anatolii, Katrich, Victor, Sidorov, Vadim, Gromovoy, Taras
• Format: Article
• Language: English
• Subjects: Antioxidants; Biochemical characteristics; Biological activity; Body mass; Body temperature; Colostrum; Glutathione peroxidase; Intoxication; Lipid peroxidation; Molecular modelling; Physiology; Protein composition; Proteins
• ISSN: 2504-5687; 2504-5695
• DOI: 10.21303/2504-5695.2021.001738

The protein composition in the diapason of molecular masses from 4800 to 9500 Dа has been studied in colostrum, taken from different cows, and manifested the expressed biological activity. For this aim, an influence of low-molecular components of colostrum on some physiological parameters (change of body mass and temperature) at intoxication of animals (Wistar rats) by blue stone has been studied. An influence of colostrum low-molecular components on parameters of the organism redox-system (content of hyperperoxides of lipids and activity of glutathione peroxidase) in the blood serum of animals has been studied. For determining integral characteristics of colostrum components, electric conductivity of skim colostrum and one of colostrum with low-molecular proteins (less than 10 000 Dа), taken from different cows, were used. The aim of this work is to study interconnections of an influence of colostrum low-molecular proteins on models of organism intoxication by cooper ions. It is demonstrated, that the colostrum composition includes 25–35 different proteins with a molecular mass from 4800 to 9500 Dа. The number and ratio between protein fractions depend on individual physiological-biochemical characteristics of producers. It has been revealed, that there is no direct dependence between the protein content in a measuring cell (2 mg/ml, 4 mg/ml and 10 mg/ml) with skim colostrum and electric conductivity change, and this dependence is different for skim colostrum, taken from different cows. Individual differences are manifested both at electric conductivity change and by the content of colostrum low-molecular proteins in a measuring cell. It is demonstrated, that colostrum low-molecular components can eliminate the toxic effect of blue stone on the organism, which mechanisms are connected with a balance shift in the system “prooxidants↔antioxidants” towards antioxidants. The electric conductivity of colostrum components may be used as an express-method for evaluating biologically active substances of colostrum