Hydrophilic lycopene-coated layered double hydroxide nanoparticles to enhance the antioxidant activity and the oxidative stress evaluation

Lycopene is well known as an efficient natural antioxidant; however, its hydrophobic structure limits intestinal absorption through the epithelium by conventional food. Oil-based edibles containing tomato increase the bioavailability of lycopene; therefore, the preparation of emulsions emerged as a...

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Bibliographic Details
Published in:Applied nanoscience 2021-11, Vol.11 (11), p.2747-2758
Main Authors: Gutiérrez Galán, Dayne Kassandra, Pacheco-Moisés, Fermín P., Silva Bezerra, Frank, Alves de Matos, Natália, González Rojas, Norma Alejandra, Arratia-Quijada, Jenny, Carbajal Arízaga, Gregorio Guadalupe
Format: Article
Language:English
Subjects:
Antioxidants
Bioavailability
Chemistry and Materials Science
Composite materials
Composition
Emulsions
Hydroxides
Magnesium
Materials Science
Membrane Biology
Nanochemistry
Nanoparticles
Nanotechnology
Nanotechnology and Microengineering
Original Article
Oxidative stress
Zeta potential
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Summary:Lycopene is well known as an efficient natural antioxidant; however, its hydrophobic structure limits intestinal absorption through the epithelium by conventional food. Oil-based edibles containing tomato increase the bioavailability of lycopene; therefore, the preparation of emulsions emerged as a solution to prepare lycopene supplements. This work reports the preparation of a composite with lycopene and layered double hydroxides (LDH) nanoparticles. Four LDH compositions were studied of which MgAl–Cl, MgAl–CO 3 , ZnAl–Cl and ZnAl–CO 3 , were their combinations. Hydrodynamic size and zeta potential were measured in aqueous suspensions for all the composites. Lycopene maintains its antioxidant capability within the magnesium-based composites and it is synergized in the zinc-containing LDHs. The improved hydrodispersability of the composites allowed us to assess the antioxidant capacity and the oxidative stress protection in conventional aqueous assays, which are limited for traditional oily lycopene formulations. The cation composition of the LDH influenced the antioxidant capacity; however, those containing magnesium presented a non-toxic performance in the oxidative stress assays. The obtained composites demonstrated to be an alternative to design lycopene aqueous formulations or increase its bioavailability.
ISSN:2190-5509
2190-5517
DOI:10.1007/s13204-021-02205-8