Atypical preeclampsia with systemic lupus erythematosus and elevated soluble fms‐like tyrosine kinase 1/placental growth factor ratio

While systemic lupus erythematosus is often complicated by preeclampsia, it is difficult to differentiate between its exacerbation and preeclampsia. The soluble fms‐like tyrosine kinase 1 (sFlt‐1)/placental growth factor (PlGF) ratio is unknown in systemic lupus erythematosus with preeclampsia befor...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2021-12, Vol.47 (12), p.4461-4466
Main Authors: Mimura, Kazuya, Tomimatsu, Takuji, Endo, Masayuki, Kimura, Tadashi
Format: Article
Language:English
Subjects:
atypical
Biomarkers
Differential diagnosis
Female
Fetuses
Gestation
Growth factors
Humans
Lupus
Lupus Erythematosus, Systemic - diagnosis
Placenta
Placenta Growth Factor
placental growth factor
Pre-eclampsia
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Protein-tyrosine kinase
soluble fms‐like tyrosine kinase 1
Systemic lupus erythematosus
Vascular Endothelial Growth Factor Receptor-1
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Summary:While systemic lupus erythematosus is often complicated by preeclampsia, it is difficult to differentiate between its exacerbation and preeclampsia. The soluble fms‐like tyrosine kinase 1 (sFlt‐1)/placental growth factor (PlGF) ratio is unknown in systemic lupus erythematosus with preeclampsia before 20 weeks of gestation. Three nulliparous women with systemic lupus erythematosus developed preeclampsia at 13, 13, and 17 weeks of gestation with sFlt‐1/PlGF ratios of 427, 865, and 525, respectively. Two patients terminated their pregnancies and delivered within 2 weeks, while one experienced intrauterine fetal death 4 weeks after the measurements. Their symptoms gradually improved, and all patients were discharged within 3 months. The sFlt‐1/PlGF ratio may be used in the differential diagnosis of preeclampsia and systemic lupus erythematosus exacerbation before 20 weeks of gestation.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15055