Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through se...

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Bibliographic Details
Published in:Biocell 2022, Vol.46 (3), p.677-687
Main Authors: HASSANI, ABDELKADER, ASLINA HUSSAIN, SITI, SADIQ AL-QUBAISI, MOTHANNA, LAKHDER BELFAR, MOHAMED, BELKHALFA, HAKIM, HAMMAD ENEZEI, HAMID, ZENTOU, HAMID, NABEEL IBRAHIM, WISAM, ALMONEM DOOLAANEA, ABD
Format: Article
Language:English
Subjects:
Angiotensin
Antioxidants
Bleaching
Breast cancer
Cancer
Colon cancer
Curcumin
Cytotoxicity
Gums
Liver cancer
Nanoparticles
Nitric oxide
Oxidative stress
Peptidyl-dipeptidase A
Tumor cell lines
β-Carotene
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Summary:The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.
ISSN:1667-5746
0327-9545
DOI:10.32604/biocell.2022.016848