Sensitivity enhancement in rGO/Mn3O4 hybrid nanocomposites: A modified glassy carbon electrode for the simultaneous detection of dopamine and uric acid

A high sensitive electrochemical sensor was designed for the real time detection of dopamine (DA) and uric acid (UA) by using the Nanocomposite (NC) of reduced graphene oxide nano-octahedral shaped Mn3O4 modified Glassy Carbon Electrode (rGO/Mn3O4/GCE). The effect of Mn3O4 on the electrochemical and...

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Bibliographic Details
Published in:Synthetic metals 2021-10, Vol.280, p.116859, Article 116859
Main Authors: Vinodhkumar, G., Jose, Sujin P., Lokeswarareddy, S., Sekar, C., Potheher, I. Vetha, Peter, A. Cyrac
Format: Article
Language:English
Subjects:
Chemical sensors
Dopamine
Electrochemical detection
Glassy carbon
Graphene
Manganese oxides
Mn3O4
Nanocomposites
Physical properties
Reduced graphene oxide
Selectivity
Sensitivity enhancement
Uric acid
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Summary:A high sensitive electrochemical sensor was designed for the real time detection of dopamine (DA) and uric acid (UA) by using the Nanocomposite (NC) of reduced graphene oxide nano-octahedral shaped Mn3O4 modified Glassy Carbon Electrode (rGO/Mn3O4/GCE). The effect of Mn3O4 on the electrochemical and physical properties of rGO/Mn3O4 NC by Mn3O4 contents was analyzed by varying the molar ratio of Mn precursor (1, 5 and 10 mM denoted as GM1:1, GM1:5 and GM1:10 respectively). Due to the unique morphology and physical properties originated from Mn3O4, GM1:10/GCE revealed enhanced electrochemical response in terms of large peak potential separation, high selectivity and sensitivity. The GM1:10/GCE displayed a distinct SWV response to DA and UA for 1–600 μM at lowest detection limit of 1.42 μM and 0.76 μM. Additionally, anti-interference property of the designed sensor against electroactive molecules is found to be excellent stability and good reproducibility. Finally, it was make use for the detection of DA and UA in the pharmaceutical compound and physiological residue. •A novel hybrid rGO/Mn3O4 nancomposites were fabricated by simple solvothermal method.•The shape controlled Mn3O4 NPs present on rGO sheet shows an enhanced electrochemical detection of dopamine and uric acid.•The sensor was successfully employed for real time analysis with dopamine hydrochloride injection and human urine samples.
ISSN:0379-6779
1879-3290
DOI:10.1016/j.synthmet.2021.116859